Literature DB >> 19647511

Ras and the FAK paradox.

Marc A Antonyak1, Richard A Cerione.   

Abstract

In a recent issue of Molecular Cell, Zheng et al. (2009) describe a surprising set of findings that highlight an unexpected negative regulation of FAK by oncogenic Ras and its consequences for cancer cell migration and invasion.

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Year:  2009        PMID： 19647511      PMCID： PMC3065190          DOI： 10.1016/j.molcel.2009.07.005

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation.

Authors:  R G Qiu; A Abo; F McCormick; M Symons
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

2.  Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.

Authors:  Qiyu Feng; Dan Baird; Xu Peng; Jianbin Wang; Thi Ly; Jun-Lin Guan; Richard A Cerione
Journal:  Nat Cell Biol       Date:  2006-08-06       Impact factor: 28.824

3.  FAK integrates growth-factor and integrin signals to promote cell migration.

Authors:  D J Sieg; C R Hauck; D Ilic; C K Klingbeil; E Schaefer; C H Damsky; D D Schlaepfer
Journal:  Nat Cell Biol       Date:  2000-05       Impact factor: 28.824

4.  Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation.

Authors:  R Khosravi-Far; P A Solski; G J Clark; M S Kinch; C J Der
Journal:  Mol Cell Biol       Date:  1995-11       Impact factor: 4.272

5.  Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L.

Authors:  Jian-Bin Wang; Wen Jin Wu; Richard A Cerione
Journal:  J Biol Chem       Date:  2005-04-11       Impact factor: 5.157

6.  FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.

Authors:  Yanhua Zheng; Yan Xia; David Hawke; Maxime Halle; Michel L Tremblay; Xiang Gao; Xiao Zhen Zhou; Kenneth Aldape; Melanie H Cobb; Keping Xie; Jie He; Zhimin Lu
Journal:  Mol Cell       Date:  2009-07-10       Impact factor: 17.970

7.  Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.

Authors:  A Minden; A Lin; F X Claret; A Abo; M Karin
Journal:  Cell       Date:  1995-06-30       Impact factor: 41.582

Review 8.  Signal transduction by focal adhesion kinase in cancer.

Authors:  Jihe Zhao; Jun-Lin Guan
Journal:  Cancer Metastasis Rev       Date:  2009-06       Impact factor: 9.264

9.  Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice.

Authors:  D Ilić; Y Furuta; S Kanazawa; N Takeda; K Sobue; N Nakatsuji; S Nomura; J Fujimoto; M Okada; T Yamamoto
Journal:  Nature       Date:  1995-10-12       Impact factor: 49.962

10.  Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion.

Authors:  Hajime Yano; Yuichi Mazaki; Kazuo Kurokawa; Steven K Hanks; Michiyuki Matsuda; Hisataka Sabe
Journal:  J Cell Biol       Date:  2004-07-19       Impact factor: 10.539
  10 in total
  4 in total

1.  Anti-metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA-MB-231 cells.

Authors:  Chao Sun; Hongxia Cui; Hongyan Yang; Xiaohui DU; Liling Yue; Jicheng Liu; Y U Lin
Journal:  Oncol Lett       Date:  2015-06-02       Impact factor: 2.967

2.  Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.

Authors:  Yanhua Zheng; Weiwei Yang; Yan Xia; David Hawke; David X Liu; Zhimin Lu
Journal:  Mol Cell Biol       Date:  2011-08-29       Impact factor: 4.272

Review 3.  FAK and paxillin, two potential targets in pancreatic cancer.

Authors:  Rajani Kanteti; Surinder K Batra; Frances E Lennon; Ravi Salgia
Journal:  Oncotarget       Date:  2016-05-24

4.  Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions.

Authors:  Ho-Kai Huang; Yi-Hsin Lin; Heng-Ai Chang; Yi-Shyun Lai; Ying-Chi Chen; Soon-Cen Huang; Cheng-Yang Chou; Wen-Tai Chiu
Journal:  J Biomed Sci       Date:  2020-02-21       Impact factor: 8.410
  4 in total

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