BACKGROUND: The measurement of carotid intima-medial thickness is a well-validated measure of cardiovascular risk. Although atherosclerosis occurs in the intima, this arterial layer is not measured alone because of the limitation in ultrasound resolution with standard-frequency probes. METHODS: We evaluated the feasibility of using a 55-MHz ultrasound system with high resolution to measure intima thickness in several vascular territories compared with a "standard" frequency probe. RESULTS: The intima-medial thickness was measured in the brachial, radial, and tibial arteries in 10 healthy subjects and 5 subjects with peripheral arterial disease. The high-frequency ultrasound probe showed superior resolution compared with the standard-frequency probe, allowing for measurement of intima separately from media. CONCLUSION: The intima can be measured independently of media with a high degree of reproducibility using a high-frequency probe. This technology may allow for early detection of cardiovascular risk and extend knowledge about the physiologic changes in early atherosclerotic development.
BACKGROUND: The measurement of carotid intima-medial thickness is a well-validated measure of cardiovascular risk. Although atherosclerosis occurs in the intima, this arterial layer is not measured alone because of the limitation in ultrasound resolution with standard-frequency probes. METHODS: We evaluated the feasibility of using a 55-MHz ultrasound system with high resolution to measure intima thickness in several vascular territories compared with a "standard" frequency probe. RESULTS: The intima-medial thickness was measured in the brachial, radial, and tibial arteries in 10 healthy subjects and 5 subjects with peripheral arterial disease. The high-frequency ultrasound probe showed superior resolution compared with the standard-frequency probe, allowing for measurement of intima separately from media. CONCLUSION: The intima can be measured independently of media with a high degree of reproducibility using a high-frequency probe. This technology may allow for early detection of cardiovascular risk and extend knowledge about the physiologic changes in early atherosclerotic development.
Authors: Mary J Roman; Tasneem Z Naqvi; Julius M Gardin; Marie Gerhard-Herman; Michael Jaff; Emile Mohler Journal: Vasc Med Date: 2006-11 Impact factor: 3.239
Authors: Walter Osika; Frida Dangardt; Julia Grönros; Ulf Lundstam; Anna Myredal; Mats Johansson; Reinhard Volkmann; Tomas Gustavsson; Li Ming Gan; Peter Friberg Journal: Arterioscler Thromb Vasc Biol Date: 2006-12-28 Impact factor: 8.311
Authors: R Corti; Z A Fayad; V Fuster; S G Worthley; G Helft; J Chesebro; M Mercuri; J J Badimon Journal: Circulation Date: 2001-07-17 Impact factor: 29.690
Authors: Pernette R W de Sauvage Nolting; Eric de Groot; Aeilko H Zwinderman; Rudolf J A Buirma; Mieke D Trip; John J P Kastelein Journal: Arch Intern Med Date: 2003 Aug 11-25
Authors: E J Gussenhoven; P A Frietman; S H The; R J van Suylen; F C van Egmond; C T Lancée; H van Urk; J R Roelandt; T Stijnen; N Bom Journal: Am J Cardiol Date: 1991-12-15 Impact factor: 2.778