ETHNOPHARMACOLOGICAL RELEVANCE: The herb of Chelidonium majus Linn is known to possess a variety of biological activities and applied in the therapy of various infectious diseases. AIM OF THE STUDY: To evaluate the in vitro antifungal activity of the active components from Chelidonium majus against clinical drug-resistant yeast isolates. MATERIALS AND METHODS: Active compounds were obtained using bioassay-guided method. Six species of yeast fungi were exposed to the compounds. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined according to the standard broth microdilution method. RESULTS: Of the six compounds determined, 8-hydroxydihydrosanguinarine (1) and 8-hydroxydihydrochelerythrine (2) demonstrated potent activity with the MIC ranges of 2-80 and 4-100 microg/mL, respectively. Dihydrosanguinarine (3), dihydrochelerythrine (4), sanguinarine (5) and chelerythrine (6) had some degree of antifungal activity. CONCLUSIONS: The overall results provided important information for the potential application of the 8-hydroxylated alkaloids from Chelidonium majus in the therapy of serious infection caused by drug-resistant fungi.
ETHNOPHARMACOLOGICAL RELEVANCE: The herb of Chelidonium majus Linn is known to possess a variety of biological activities and applied in the therapy of various infectious diseases. AIM OF THE STUDY: To evaluate the in vitro antifungal activity of the active components from Chelidonium majus against clinical drug-resistant yeast isolates. MATERIALS AND METHODS: Active compounds were obtained using bioassay-guided method. Six species of yeast fungi were exposed to the compounds. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined according to the standard broth microdilution method. RESULTS: Of the six compounds determined, 8-hydroxydihydrosanguinarine (1) and 8-hydroxydihydrochelerythrine (2) demonstrated potent activity with the MIC ranges of 2-80 and 4-100 microg/mL, respectively. Dihydrosanguinarine (3), dihydrochelerythrine (4), sanguinarine (5) and chelerythrine (6) had some degree of antifungal activity. CONCLUSIONS: The overall results provided important information for the potential application of the 8-hydroxylated alkaloids from Chelidonium majus in the therapy of serious infection caused by drug-resistant fungi.
Authors: Moutoshi Chakraborty; S M Fajle Rabby; Dipali Rani Gupta; Mahfuzur Rahman; Sanjoy Kumar Paul; Nur Uddin Mahmud; Abdullah Al Mahbub Rahat; Ljupcho Jankuloski; Tofazzal Islam Journal: Microorganisms Date: 2022-06-09
Authors: Melyssa Negri; Tânia P Salci; Cristiane S Shinobu-Mesquita; Isis R G Capoci; Terezinha I E Svidzinski; Erika Seki Kioshima Journal: Molecules Date: 2014-03-07 Impact factor: 4.411
Authors: Sylwia Zielińska; Anna Jezierska-Domaradzka; Magdalena Wójciak-Kosior; Ireneusz Sowa; Adam Junka; Adam M Matkowski Journal: Front Pharmacol Date: 2018-04-11 Impact factor: 5.810