| Literature DB >> 19646869 |
Karin Worm1, Damian G Weaver, Rosalyn C Green, Christopher T Saeui, Doreen-Marie S Dulay, William M Barker, Joel A Cassel, Gabriel J Stabley, Robert N DeHaven, Christopher J LaBuda, Michael Koblish, Bernice L Brogdon, Steven A Smith, Roland E Dolle.
Abstract
Recently sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Replacing the sulfonamide functionality and reversing the original carboxamide bond led to the discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB(2) agonists. Selective CB(2) agonist 31 (K(i)=2.7; CB(1)/CB(2)=190) displayed robust activity in a rodent model of postoperative pain.Entities:
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Year: 2009 PMID： 19646869 DOI： 10.1016/j.bmcl.2009.07.057
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823