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Literature DB >> 19646811

Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1.

Thomas J Wilson¹, Kalyan C Nannuru, Mitsuru Futakuchi, Rakesh K Singh.

Abstract

Transforming growth factor (TGF)-beta signaling makes a significant contribution to the pathogenesis of breast cancer bone metastasis. In other tumor types, TGF-beta has been shown to promote tumor vascularity. Here, we report that inhibition of TGF-beta significantly reduces microvessel density in mammary tumor-induced bone lesions, mediated by decreased expression of both vascular endothelial growth factor (VEGF) and monocyte chemotactic protein (MCP)-1, both known angiogenic factors. Cathepsin G upregulation at the tumor-bone interface has been linked to increased TGF-beta signaling, and we also report that inhibition of Cathepsin G reduced tumor vascularity, as well as VEGF and MCP-1 expression. 2009 Elsevier Ireland Ltd. All rights reserved.

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Year: 2009 PMID： 19646811 PMCID： PMC2815079 DOI： 10.1016/j.canlet.2009.06.035

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

25 in total

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Authors: J S de Jong; P J van Diest; J P Baak
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2. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Authors: Q Yu; I Stamenkovic
Journal: Genes Dev Date: 2000-01-15 Impact factor: 11.361

3. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.

Authors: T Sánchez-Elsner; L M Botella; B Velasco; A Corbí; L Attisano; C Bernabéu
Journal: J Biol Chem Date: 2001-08-02 Impact factor: 5.157

4. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.

Authors: R Salcedo; M L Ponce; H A Young; K Wasserman; J M Ward; H K Kleinman; J J Oppenheim; W J Murphy
Journal: Blood Date: 2000-07-01 Impact factor: 22.113

5. Astrocyte invasion and vasculogenesis in the developing ferret retina.

Authors: K Kopatz; C Distler
Journal: J Neurocytol Date: 2000-03

6. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP).

Authors: Jianli Niu; Asim Azfer; Olga Zhelyabovska; Sumbul Fatma; Pappachan E Kolattukudy
Journal: J Biol Chem Date: 2008-03-24 Impact factor: 5.157

7. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.

Authors: Yoshiaki Kubota; Masanori Hirashima; Kazuo Kishi; Colin L Stewart; Toshio Suda
Journal: J Clin Invest Date: 2008-07 Impact factor: 14.808

8. Pattern of tumor recurrence in initially nonmetastatic breast cancer patients: distribution and frequency of metastases at unusual sites.

Authors: Naoko Sanuki-Fujimoto; Atsuya Takeda; Atsushi Amemiya; Toru Ofuchi; Masato Ono; Ryo Yamagami; Jun Hatayama; Etsuo Kunieda; Naoyuki Shigematsu
Journal: Cancer Date: 2008-08-15 Impact factor: 6.860

9. Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation.

Authors: Mitsuru Futakuchi; Kalyan C Nannuru; Michelle L Varney; Anguraj Sadanandam; Kimihisa Nakao; Kiyofumi Asai; Tomoyuki Shirai; Shin-ya Sato; Rakesh K Singh
Journal: Cancer Sci Date: 2008-11-25 Impact factor: 6.716

10. Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.

Authors: Thomas J Wilson; Kalyan C Nannuru; Rakesh K Singh
Journal: Mol Cancer Res Date: 2009-08-11 Impact factor: 5.852

26 in total

Review 1. The role of cytokines in breast cancer development and progression.

Authors: Marcela Esquivel-Velázquez; Pedro Ostoa-Saloma; Margarita Isabel Palacios-Arreola; Karen E Nava-Castro; Julieta Ivonne Castro; Jorge Morales-Montor
Journal: J Interferon Cytokine Res Date: 2014-07-28 Impact factor: 2.607

2. miR-200b and cancer/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs.

Authors: Youngmi Kim; Deokbum Park; Hyuna Kim; Munseon Choi; Hansoo Lee; Yun Sil Lee; Jongseon Choe; Young Myeong Kim; Dooil Jeoung
Journal: J Biol Chem Date: 2013-10-30 Impact factor: 5.157

3. Lysyl Oxidase Is Predictive of Unfavorable Outcomes and Essential for Regulation of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.

Authors: Jiye Zhu; Shan Huang; Guobin Wu; Chaoyuan Huang; Xianjian Li; Zhigang Chen; Lei Zhao; Yinnong Zhao
Journal: Dig Dis Sci Date: 2015-06-06 Impact factor: 3.199

Review 4. Tumor-stromal interactions in bone metastasis.

Authors: Kalyan C Nannuru; Rakesh K Singh
Journal: Curr Osteoporos Rep Date: 2010-06 Impact factor: 5.096

5. The Tumor-Promoting Flow of Cells Into, Within and Out of the Tumor Site: Regulation by the Inflammatory Axis of TNFα and Chemokines.

Authors: Adit Ben-Baruch
Journal: Cancer Microenviron Date: 2011-12-22

6. Renovascular disease, microcirculation, and the progression of renal injury: role of angiogenesis.

Authors: Alejandro R Chade
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2011-02-09 Impact factor: 3.619

7. The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-β1 signaling: implications in hepatocellular carcinogenesis.

Authors: Elsa M Reyes-Reyes; Irma N Ramos; Marco A Tavera-Garcia; Kenneth S Ramos
Journal: Am J Cancer Res Date: 2016-05-01 Impact factor: 6.166