Literature DB >> 19646797

Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety.

P Manojkumar1, T K Ravi, S Gopalakrishnan.   

Abstract

A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showed good antibacterial activity and compound 5e was found to be the most active antioxidant in the series, and thus represent a new class of promising lead compounds.

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Year:  2009        PMID： 19646797     DOI： 10.1016/j.ejmech.2009.07.004

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  Erratum to: Nonuse of dental service by schoolchildren in Southern Brazil: impact of socioeconomics, behavioral and clinical factors.

Authors:  Vanessa Polina Pereira da Costa; Marília Leão Goettems; Luísa Jardim Corrêa de Oliveira; Sandra Beatriz Chaves Tarquinio; Dione Dias Torriani; Marcos Britto Correa; Flávio Fernando Demarco
Journal:  Int J Public Health       Date:  2015-09       Impact factor: 3.380

2.  Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study.

Authors:  Omar A El-Khouly; Morkos A Henen; Magda A-A El-Sayed; Mona I Shabaan; Shahenda M El-Messery
Journal:  Bioorg Med Chem       Date:  2020-12-27       Impact factor: 3.641

3.  Anti-UVC irradiation and metal chelation properties of 6-benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: an implications for anti-cataract agent.

Authors:  Jiahn-Haur Liao; Tzu-Hua Wu; Feng-Lin Hsu; Yi-Shiang Huang; Po-Hung Chiang; Zih-You Huang; Chi-Hsien Huang; Shih-Hsiung Wu; Mei-Hsiang Lin
Journal:  Int J Mol Sci       Date:  2011-10-21       Impact factor: 5.923

4.  Design, synthesis, DFT, docking studies and ADME prediction of some new coumarinyl linked pyrazolylthiazoles: Potential standalone or adjuvant antimicrobial agents.

Authors:  Sunil Kumar; Vikram Saini; Indresh K Maurya; Jayant Sindhu; Mukesh Kumari; Ramesh Kataria; Vinod Kumar
Journal:  PLoS One       Date:  2018-04-19       Impact factor: 3.240

5.  Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives.

Authors:  Mohamed A M Abdel Reheim; Safaa M Baker
Journal:  Chem Cent J       Date:  2017-11-02       Impact factor: 4.215

6.  Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies.

Authors:  Ismail M M Othman; Mohamed A M Gad-Elkareem; Abd El-Galil E Amr; Mohamed A Al-Omar; Eman S Nossier; Elsayed A Elsayed
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

7.  Microwave assisted synthesis of novel pyrazolone derivatives attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities.

Authors:  Rishikesh V Antre; A Cendilkumar; Divakar Goli; Ganesh S Andhale; Rajesh J Oswal
Journal:  Saudi Pharm J       Date:  2011-06-25       Impact factor: 4.330

8.  Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one.

Authors:  K K Sivakumar; A Rajasekharan; R Rao; B Narasimhan
Journal:  Indian J Pharm Sci       Date:  2013-07       Impact factor: 0.975

9.  3-Oxo-N',2-diphenyl-2,3-di-hydro-1H-pyrazole-4-carbohydrazide.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Eman A Ahmed; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-06-25
  9 in total

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