BACKGROUND: Clinical trials addressing the acneiform rash associated with epidermal growth factor receptor inhibitors are lacking. OBJECTIVE: We evaluated the ability of topical pimecrolimus to reduce the severity of cetuximab-related facial rash. METHODS: In all, 24 patients with metastatic colorectal cancer with cetuximab facial rash received twice daily pimecrolimus application for 5 weeks to half of the face. At baseline, week 2, and week 5, a dermatologist performed facial lesion counts, patients reported perceived severity of rash-related symptoms, and standardized facial photographs were obtained for blinded evaluation of global rash severity. RESULTS: Treatment sides had greater decrease in lesion counts than observation sides of face at weeks 2 (P < .001) and 5 (P = .02). However, there were no significant differences in patients' assessment of symptoms and in review of facial photographs for rash severity between treatment and observation sides. LIMITATIONS: This study was not placebo controlled. CONCLUSIONS:Pimecrolimus application did not translate into clinically meaningful benefit for patients with cetuximab-related facial rash.
RCT Entities:
BACKGROUND: Clinical trials addressing the acneiform rash associated with epidermal growth factor receptor inhibitors are lacking. OBJECTIVE: We evaluated the ability of topical pimecrolimus to reduce the severity of cetuximab-related facial rash. METHODS: In all, 24 patients with metastatic colorectal cancer with cetuximabfacial rash received twice daily pimecrolimus application for 5 weeks to half of the face. At baseline, week 2, and week 5, a dermatologist performed facial lesion counts, patients reported perceived severity of rash-related symptoms, and standardized facial photographs were obtained for blinded evaluation of global rash severity. RESULTS: Treatment sides had greater decrease in lesion counts than observation sides of face at weeks 2 (P < .001) and 5 (P = .02). However, there were no significant differences in patients' assessment of symptoms and in review of facial photographs for rash severity between treatment and observation sides. LIMITATIONS: This study was not placebo controlled. CONCLUSIONS:Pimecrolimus application did not translate into clinically meaningful benefit for patients with cetuximab-related facial rash.
Authors: Z Reguiai; J B Bachet; C Bachmeyer; L Peuvrel; M Beylot-Barry; M Bezier; E Boucher; C Chevelle; P Colin; R Guimbaud; L Mineur; M A Richard; P Artru; P Dufour; J M Gornet; E Samalin; R J Bensadoun; M Ychou; T André; B Dreno; O Bouché Journal: Support Care Cancer Date: 2012-04-27 Impact factor: 3.603
Authors: Yevgeniy Balagula; Katherine Barth Huston; Klaus J Busam; Mario E Lacouture; Paul B Chapman; Patricia L Myskowski Journal: Invest New Drugs Date: 2010-10-27 Impact factor: 3.850
Authors: Mario E Lacouture; Milan J Anadkat; René-Jean Bensadoun; Jane Bryce; Alexandre Chan; Joel B Epstein; Beth Eaby-Sandy; Barbara A Murphy Journal: Support Care Cancer Date: 2011-06-01 Impact factor: 3.603
Authors: Thomas C Wehler; Claudine Graf; Markus Möhler; Jutta Herzog; Martin R Berger; Ines Gockel; Hauke Lang; Matthias Theobald; Peter R Galle; Carl C Schimanski Journal: J Cancer Res Clin Oncol Date: 2013-08-07 Impact factor: 4.553