| Literature DB >> 1964674 |
A Ishii1, T Nakagawa, F Nambu, M Motoishi, T Miyamoto.
Abstract
The inhibitory effect of ONO-1078, a novel leukotriene (LT) receptor antagonist, was investigated on guinea pig lung anaphylaxis in vitro and in vivo. It was demonstrated that this compound could inhibit the late phase of contractile responses in Schultz-Dale reactions and endogenous LT-mediated bronchoconstrictions in passively sensitized guinea pigs, in a dose-dependent fashion, implying its clinical usefulness in the treatment of human bronchial asthma.Entities:
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Year: 1990 PMID： 1964674 DOI： 10.1159/000235172
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915