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Literature DB >> 196467

Effect of potassium on human and rat liver glucose-6-phosphatase.

P J Collipp, F Finkelstein, S Y Chen, V T Maddaiah.

Abstract

Potassium chloride concentrations of 100-150 mM were shown to inhibit (20-40%) human and rat liver microsomal glucose-6-phosphatase when the substrate was reduced to physiological concentration. When the enzyme was solubilized by treatment of microsomes with A12O3 the inhibition could be observed at greater substrate concentrations. Since potassium deprivation is associated with hyperglycemia in both animals and man, these observations may have physiological significance.

Entities: Chemical Disease Gene Species

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Year: 1976 PMID： 196467 DOI： 10.1007/bf02581120

Source DB: PubMed Journal: Acta Diabetol Lat ISSN： 0001-5563

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References

16 in total

1. The effect of a single dose of a long-acting anabolic steroid (Anadur) in patients with osteoporosis.

Authors: U SAGILD
Journal: Acta Med Scand Date: 1963-03

2. Intracellular distribution of enzymes. IX. Certain purine-metabolizing enzymes.

Authors: W C SCHNEIDER; G H HOGEBOOM
Journal: J Biol Chem Date: 1952-03 Impact factor: 5.157

3. Diagnosis of glycogen storage disease type I by serum immunodiffusion.

Authors: P J Collipp; S Y Chen; V T Maddaiah; J Thomas; F J Huijing
Journal: Pediatrics Date: 1974-01 Impact factor: 7.124

4. Activation of microsomal glucose-6-phosphatase and associated pyrophosphatase and pyrophosphate-glucose phosphotransferase activities of human liver by aluminum oxide.

Authors: S Y Chen; P J Collipp; V T Maddaiah; I Rezvani; J L Duffy
Journal: Biochem Med Date: 1971-06

Effect of potassium on human and rat liver glucose-6-phosphatase.

1. The effect of a single dose of a long-acting anabolic steroid (Anadur) in patients with osteoporosis.

2. Intracellular distribution of enzymes. IX. Certain purine-metabolizing enzymes.

3. Diagnosis of glycogen storage disease type I by serum immunodiffusion.

4. Activation of microsomal glucose-6-phosphatase and associated pyrophosphatase and pyrophosphate-glucose phosphotransferase activities of human liver by aluminum oxide.

5. Organ culture of fetal rat pancreas. I. Insulin release induced by caffeine and by sugars and some derivatives.

6. KCl reversal of insulin inhibition and fade in pentagastrin-stimulated gastric secretion.

7. The effect of potassium chloride infusion on insulin secretion in vivo.

8. Hypertension, the potassium ion and impaired carbohydrate tolerance.

9. Cation requirements for insulin secretion in the isolated perfused pancreas.

10. The role of sodium and potassium in insulin secretion from rabbit pancreas.