BACKGROUND: We previously demonstrated relatively intact cognitive function (with the exception of suggestive evidence for persistent deficits in spatial information processing) in middle-aged long-term abstinent alcoholics (LTAA, abstinent for 6 months or more) compared to age and gender comparable nonalcoholic controls (NAC) (Fein et al., 2006). METHODS: In the current study, we examine cortical gray matter volumes in the same samples to determine whether gray matter volumes in LTAA are consistent with the cognitive results--i.e., exhibiting gray matter volumes comparable to NAC in most brain regions, except for possible indications of persistent shrinkage in the parietal lobe subserving spatial information processing. RESULTS: We found gray matter shrinkage in LTAA in the parietal lobe consistent with the spatial processing deficits in this same sample. More compelling, in LTAA, the magnitude of parietal gray matter shrinkage was negatively associated with spatial processing domain performance and positively associated with alcohol dose. Gray matter volume deficits were present in the occipital and other cortical tissue, but poorer visuospatial test performance correlated significantly with smaller volumes in the parietal cortex only. CONCLUSIONS: Taken together, the cognitive and structural imaging data provide compelling evidence that chronic alcohol abuse results in shrinkage of the parietal cortex with associated deficits in spatial information processing.
BACKGROUND: We previously demonstrated relatively intact cognitive function (with the exception of suggestive evidence for persistent deficits in spatial information processing) in middle-aged long-term abstinent alcoholics (LTAA, abstinent for 6 months or more) compared to age and gender comparable nonalcoholic controls (NAC) (Fein et al., 2006). METHODS: In the current study, we examine cortical gray matter volumes in the same samples to determine whether gray matter volumes in LTAA are consistent with the cognitive results--i.e., exhibiting gray matter volumes comparable to NAC in most brain regions, except for possible indications of persistent shrinkage in the parietal lobe subserving spatial information processing. RESULTS: We found gray matter shrinkage in LTAA in the parietal lobe consistent with the spatial processing deficits in this same sample. More compelling, in LTAA, the magnitude of parietal gray matter shrinkage was negatively associated with spatial processing domain performance and positively associated with alcohol dose. Gray matter volume deficits were present in the occipital and other cortical tissue, but poorer visuospatial test performance correlated significantly with smaller volumes in the parietal cortex only. CONCLUSIONS: Taken together, the cognitive and structural imaging data provide compelling evidence that chronic alcohol abuse results in shrinkage of the parietal cortex with associated deficits in spatial information processing.
Authors: G Fein; V Di Sclafani; V A Cardenas; H Goldmann; M Tolou-Shams; D J Meyerhoff Journal: Alcohol Clin Exp Res Date: 2002-04 Impact factor: 3.455
Authors: H P Erdman; M H Klein; J H Greist; S S Skare; J J Husted; L N Robins; J E Helzer; E Goldring; M Hamburger; J P Miller Journal: J Psychiatr Res Date: 1992-01 Impact factor: 4.791
Authors: K K Bucholz; L N Robins; J J Shayka; T R Przybeck; J E Helzer; E Goldring; M H Klein; J H Greist; H P Erdman; S S Skare Journal: J Psychiatr Res Date: 1991 Impact factor: 4.791
Authors: Christopher D Kroenke; Torsten Rohlfing; Byung Park; Edith V Sullivan; Adolf Pfefferbaum; Kathleen A Grant Journal: Neuropsychopharmacology Date: 2013-09-27 Impact factor: 7.853
Authors: Dardo G Tomasi; Corinde E Wiers; Ehsan Shokri-Kojori; Amna Zehra; Veronica Ramirez; Clara Freeman; Jamie Burns; Christopher Kure Liu; Peter Manza; Sung W Kim; Gene-Jack Wang; Nora D Volkow Journal: Int J Neuropsychopharmacol Date: 2019-09-01 Impact factor: 5.176
Authors: A Uhlmann; B Bandelow; D J Stein; S Bloch; K R Engel; U Havemann-Reinecke; Dirk Wedekind Journal: Eur Arch Psychiatry Clin Neurosci Date: 2018-01-25 Impact factor: 5.270