Literature DB >> 19645463

Steroidal glycosides from Agave utahensis and their cytotoxic activity.

Akihito Yokosuka1, Maki Jitsuno, Satoru Yui, Masatoshi Yamazaki, Yoshihiro Mimaki.   

Abstract

Eight new spirostanol saponins (1-8) and three new furostanol saponins (9-11) were isolated from the whole plants of Agave utahensis. The structures of 1-11 were determined by analysis of extensive spectroscopic data. The saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 showed cytotoxicity against HL-60 cells with an IC(50) value of 4.9 microg/mL, induced apoptosis in HL-60 cells, and markedly activated caspase-3.

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Year:  2009        PMID： 19645463     DOI： 10.1021/np900168d

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  AU-1 from Agavaceae plants downregulates the expression of glycolytic enzyme phosphoglycerate mutase.

Authors:  Tomofumi Fujino; Akihito Yokosuka; Harutaka Ichikawa; Toshiyuki Oshima; Yoshihiro Mimaki; Makio Hayakawa
Journal:  J Nat Med       Date:  2017-11-20       Impact factor: 2.343

2.  Saponins as cytotoxic agents: a review.

Authors:  Irma Podolak; Agnieszka Galanty; Danuta Sobolewska
Journal:  Phytochem Rev       Date:  2010-06-25       Impact factor: 5.374

3.  Fast Centrifugal Partition Chromatography Fractionation of Concentrated Agave (Agave salmiana) Sap to Obtain Saponins with Apoptotic Effect on Colon Cancer Cells.

Authors:  Liliana Santos-Zea; Oscar R Fajardo-Ramírez; Irasema Romo-López; Janet A Gutiérrez-Uribe
Journal:  Plant Foods Hum Nutr       Date:  2016-03       Impact factor: 3.921

4.  AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner.

Authors:  Tomofumi Fujino; Akihito Yokosuka; Hideaki Higurashi; Rina Yokokawa; Ryo Sakurai; Wataru Harashima; Yuichi Miki; Yasuyuki Fujiwara; Yoshihiro Mimaki; Makio Hayakawa
Journal:  J Nat Med       Date:  2016-07-07       Impact factor: 2.343

Review 5.  Potential Use of Agave Genus in Neuroinflammation Management.

Authors:  Maribel Herrera-Ruiz; Enrique Jiménez-Ferrer; Manasés González-Cortazar; Alejandro Zamilpa; Alexandre Cardoso-Taketa; Martha Lucía Arenas-Ocampo; Antonio Ruperto Jiménez-Aparicio; Nayeli Monterrosas-Brisson
Journal:  Plants (Basel)       Date:  2022-08-25

Review 6.  Recent advances in steroidal saponins biosynthesis and in vitro production.

Authors:  Swati Upadhyay; Gajendra Singh Jeena; Rakesh Kumar Shukla
Journal:  Planta       Date:  2018-05-10       Impact factor: 4.116
  6 in total

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