Literature DB >> 19644474

Therapeutic manipulation of immune tolerance in allergic disease.

Mübeccel Akdis1, Cezmi A Akdis.   

Abstract

Immune tolerance - the adaptation of the immune system to external antigens or allergens - might be therapeutically manipulated to restore normal immunity in conditions such as allergy, asthma and autoimmune diseases. The field of allergen-specific immunotherapy is experiencing exciting and novel developments for the treatment of allergic and autoimmune diseases, and recent insights into the reciprocal regulation and counter-balance between different T-cell subsets is foreseen to facilitate new strategies for immunointervention. This Review highlights current knowledge of immunomodulatory therapies for the manipulation of immune tolerance and highlights recent approaches to improve allergen-specific immunotherapy for the treatment of allergic diseases.

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Year:  2009        PMID： 19644474     DOI： 10.1038/nrd2653

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  183 in total

1.  Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation.

Authors:  R J van Neerven; T Wikborg; G Lund; B Jacobsen; A Brinch-Nielsen; J Arnved; H Ipsen
Journal:  J Immunol       Date:  1999-09-01       Impact factor: 5.422

2.  Lifetime of plasma cells in the bone marrow.

Authors:  R A Manz; A Thiel; A Radbruch
Journal:  Nature       Date:  1997-07-10       Impact factor: 49.962

3.  Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).

Authors:  Christian Möller; Sten Dreborg; Hosne A Ferdousi; Susanne Halken; Arne Høst; Lars Jacobsen; Antti Koivikko; Dieter Y Koller; Bodo Niggemann; Lene A Norberg; Radvan Urbanek; Erkka Valovirta; Ulrich Wahn
Journal:  J Allergy Clin Immunol       Date:  2002-02       Impact factor: 10.793

4.  Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

Authors:  V A Varney; Q A Hamid; M Gaga; S Ying; M Jacobson; A J Frew; A B Kay; S R Durham
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

5.  Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis.

Authors:  M Akdis; H U Simon; L Weigl; O Kreyden; K Blaser; C A Akdis
Journal:  J Immunol       Date:  1999-07-01       Impact factor: 5.422

6.  Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists.

Authors:  Emma J Peek; David F Richards; Alexander Faith; Paul Lavender; Tak H Lee; Christopher J Corrigan; Catherine M Hawrylowicz
Journal:  Am J Respir Cell Mol Biol       Date:  2005-04-21       Impact factor: 6.914

7.  Treatment of cat allergy with T-cell reactive peptides.

Authors:  P S Norman; J L Ohman; A A Long; P S Creticos; M A Gefter; Z Shaked; R A Wood; P A Eggleston; K B Hafner; P Rao; L M Lichtenstein; N H Jones; C F Nicodemus
Journal:  Am J Respir Crit Care Med       Date:  1996-12       Impact factor: 21.405

Review 8.  Targeting the MHC II presentation pathway in allergy vaccine development.

Authors:  C Rhyner; T Kündig; C A Akdis; R Crameri
Journal:  Biochem Soc Trans       Date:  2007-08       Impact factor: 5.407

9.  Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells.

Authors:  M Pierkes; I Bellinghausen; T Hultsch; G Metz; J Knop; J Saloga
Journal:  J Allergy Clin Immunol       Date:  1999-02       Impact factor: 10.793

10.  Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent.

Authors:  Jennifer Kearley; Jane E Barker; Douglas S Robinson; Clare M Lloyd
Journal:  J Exp Med       Date:  2005-11-28       Impact factor: 14.307
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  52 in total

Review 1.  Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6.

Authors:  Svetlana Chapoval; Preeta Dasgupta; Nicolas J Dorsey; Achsah D Keegan
Journal:  J Leukoc Biol       Date:  2010-03-24       Impact factor: 4.962

Review 2.  Tolerizing allergic responses in the lung.

Authors:  C M Lloyd; J R Murdoch
Journal:  Mucosal Immunol       Date:  2010-05-26       Impact factor: 7.313

3.  Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets.

Authors:  John F Ryan; Rachel Hovde; Jacob Glanville; Shu-Chen Lyu; Xuhuai Ji; Sheena Gupta; Robert J Tibshirani; David C Jay; Scott D Boyd; R Sharon Chinthrajah; Mark M Davis; Stephen J Galli; Holden T Maecker; Kari C Nadeau
Journal:  Proc Natl Acad Sci U S A       Date:  2016-01-25       Impact factor: 11.205

4.  Construction of the recombinant vaccine based on T-cell epitope encoding Der p1 and evaluation on its specific immunotherapy efficacy.

Authors:  Jinhong Zhao; Chaopin Li; Beibei Zhao; Pengfei Xu; Haifeng Xu; Lianping He
Journal:  Int J Clin Exp Med       Date:  2015-04-15

Review 5.  MicroRNAs in allergy and asthma.

Authors:  Ana Rebane; Cezmi A Akdis
Journal:  Curr Allergy Asthma Rep       Date:  2014-04       Impact factor: 4.806

6.  Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes.

Authors:  Xinyun Xu; Yuebin Ke; Jianhui Yuan; Yuefeng Liu; Xueyu Li; Desheng Wu; Xiaoyun Qin; Jiyan Mao; Kanlang Mao
Journal:  Toxicol Res (Camb)       Date:  2016-01-22       Impact factor: 3.524

7.  International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.

Authors:  Sarah K Wise; Sandra Y Lin; Elina Toskala; Richard R Orlandi; Cezmi A Akdis; Jeremiah A Alt; Antoine Azar; Fuad M Baroody; Claus Bachert; G Walter Canonica; Thomas Chacko; Cemal Cingi; Giorgio Ciprandi; Jacquelynne Corey; Linda S Cox; Peter Socrates Creticos; Adnan Custovic; Cecelia Damask; Adam DeConde; John M DelGaudio; Charles S Ebert; Jean Anderson Eloy; Carrie E Flanagan; Wytske J Fokkens; Christine Franzese; Jan Gosepath; Ashleigh Halderman; Robert G Hamilton; Hans Jürgen Hoffman; Jens M Hohlfeld; Steven M Houser; Peter H Hwang; Cristoforo Incorvaia; Deborah Jarvis; Ayesha N Khalid; Maritta Kilpeläinen; Todd T Kingdom; Helene Krouse; Desiree Larenas-Linnemann; Adrienne M Laury; Stella E Lee; Joshua M Levy; Amber U Luong; Bradley F Marple; Edward D McCoul; K Christopher McMains; Erik Melén; James W Mims; Gianna Moscato; Joaquim Mullol; Harold S Nelson; Monica Patadia; Ruby Pawankar; Oliver Pfaar; Michael P Platt; William Reisacher; Carmen Rondón; Luke Rudmik; Matthew Ryan; Joaquin Sastre; Rodney J Schlosser; Russell A Settipane; Hemant P Sharma; Aziz Sheikh; Timothy L Smith; Pongsakorn Tantilipikorn; Jody R Tversky; Maria C Veling; De Yun Wang; Marit Westman; Magnus Wickman; Mark Zacharek
Journal:  Int Forum Allergy Rhinol       Date:  2018-02       Impact factor: 3.858

Review 8.  [In vitro diagnosis and monitoring of Hymenoptera venom hyposensitization].

Authors:  M M Neis; G Wurpts; L Wilbers; H F Merk
Journal:  Hautarzt       Date:  2011-09       Impact factor: 0.751

Review 9.  Clinical immunology review series: an approach to desensitization.

Authors:  M T Krishna; A P Huissoon
Journal:  Clin Exp Immunol       Date:  2010-12-22       Impact factor: 4.330

10.  Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response.

Authors:  Kai-Chun Lin; Duen-Yi Huang; De-Wei Huang; Shiang-Jong Tzeng; Wan-Wan Lin
Journal:  J Mol Med (Berl)       Date:  2015-09-16       Impact factor: 4.599
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