Literature DB >> 1964365

PAF receptors in guinea-pig and human lung.

R G Goldie1, K E Pedersen, P J Rigby, J W Paterson.   

Abstract

The autoradiographic distribution and density of specific binding sites for the PAF receptor antagonist [3H]-WEB 2086 was assessed in non-diseased and asthmatic human lung and in guinea-pig airway tissue. In general, only very low levels of specific binding were detected in these tissues with no evidence for PAF receptors in airway smooth muscle. Asthma does not appear to involve significantly increased airway PAF receptor expression.

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Year:  1990        PMID: 1964365     DOI: 10.1007/978-3-0348-7379-6_32

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN: 0379-0363


  2 in total

1.  Quantitative assessment of increased airway microvascular permeability to 125I-labelled plasma fibrinogen induced by platelet activating factor and bradykinin.

Authors:  K E Pedersen; P J Rigby; R G Goldie
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

2.  Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.

Authors:  D W Hay; W C Hubbard; B J Undem
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

  2 in total

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