Literature DB >> 19643402

Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.

Kaei Nasu1, Akitoshi Yuge, Akitoshi Tsuno, Hisashi Narahara.   

Abstract

Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is considered to be a promising agent for the treatment of endometriosis-associated fibrosis, which is among the major pathologies caused by endometriosis.

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Year:  2009        PMID: 19643402     DOI: 10.1016/j.fertnstert.2009.06.055

Source DB:  PubMed          Journal:  Fertil Steril        ISSN: 0015-0282            Impact factor:   7.329


  18 in total

1.  Effect of simvastatin on baboon endometriosis.

Authors:  Hugh S Taylor; Myles Alderman Iii; Thomas M D'Hooghe; Asgerally T Fazleabas; Antoni J Duleba
Journal:  Biol Reprod       Date:  2017-07-01       Impact factor: 4.285

Review 2.  Novel therapies targeting endometriosis.

Authors:  Hugh S Taylor; Kevin G Osteen; Kaylon L Bruner-Tran; Charles J Lockwood; Graciela Krikun; Anna Sokalska; Antoni J Duleba
Journal:  Reprod Sci       Date:  2011-06-21       Impact factor: 3.060

3.  Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.

Authors:  Hakan Cakmak; Murat Basar; Yasemin Seval-Celik; Kevin G Osteen; Antoni J Duleba; Hugh S Taylor; Charles J Lockwood; Aydin Arici
Journal:  Reprod Sci       Date:  2012-01-19       Impact factor: 3.060

4.  Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells.

Authors:  Anna Sokalska; Amanda B Hawkins; Toshia Yamaguchi; Antoni J Duleba
Journal:  J Assist Reprod Genet       Date:  2018-12-15       Impact factor: 3.412

5.  Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells.

Authors:  Anna Sokalska; Donna H Wong; Amanda Cress; Piotr C Piotrowski; Izabela Rzepczynska; Jesus Villanueva; Antoni J Duleba
Journal:  J Clin Endocrinol Metab       Date:  2010-04-28       Impact factor: 5.958

6.  Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells.

Authors:  Jesus A Villanueva; Anna Sokalska; Amanda B Cress; Israel Ortega; Kaylon L Bruner-Tran; Kevin G Osteen; Antoni J Duleba
Journal:  J Clin Endocrinol Metab       Date:  2013-02-05       Impact factor: 5.958

7.  Dysregulated cell mechanical properties of endometrial stromal cells from endometriosis patients.

Authors:  Zhi-Yong Wu; Xiao-Mei Yang; Ming-Jun Cheng; Rong Zhang; Jun Ye; Huan Yi; Jun-Ping Ao; Zhi-Gang Zhang; Cong-Jian Xu
Journal:  Int J Clin Exp Pathol       Date:  2014-01-15

Review 8.  Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology.

Authors:  K L Bruner-Tran; J L Herington; A J Duleba; H S Taylor; K G Osteen
Journal:  Minerva Ginecol       Date:  2013-04

9.  Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis.

Authors:  Anna Sokalska; MariaPia Anderson; Jesus Villanueva; Israel Ortega; Kaylon L Bruner-Tran; Kevin G Osteen; Antoni J Duleba
Journal:  J Clin Endocrinol Metab       Date:  2013-01-21       Impact factor: 5.958

10.  Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis.

Authors:  Emine Cosar; Ramanaiah Mamillapalli; Irene Moridi; Antoni Duleba; Hugh S Taylor
Journal:  Reprod Sci       Date:  2018-03-27       Impact factor: 3.060

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