BACKGROUND: Red cell distribution width (RDW) has recently been discovered to be a novel prognostic marker in patients with heart failure. However, the relation between RDW and echocardiographic parameters in acute heart failure (AHF) has not been studied. METHODS AND RESULTS: We analyzed laboratory findings including RDW, N-terminal pro-brain natriuretic peptide (NT-proBNP), and echocardiographic parameters in 100 patients with AHF. The mean RDW was 14.2 +/- 2.0% and median NT-proBNP was 5183 pg/mL. The mean left ventricular ejection fraction was 33.1 +/- 14.5% and early mitral inflow velocity to early diastolic mitral annular velocity (E/E'), was 21.2 +/- 9.4. When the RDW was considered in tertile categories, the highest tertile group (> 14.5%) had higher E/E' (P < .001) and higher NT-proBNP (P = .02) than the lowest tertile group (< 13.2%). In multiple linear regression analysis, RDW was independently correlated with E/E' even after adjustment of other risk factors (beta-coefficient 0.431, P = .001). The optimal cutoff value of RDW for predicting E/E' > 15, suggesting elevated left ventricular filling pressure (LVFP) was 13.45% (area under the curve 0.633, P < .05). An additive power of RDW with NT-proBNP for predicting E/E' > 15 was found in logistic regression analysis (P = .038). CONCLUSIONS: We found a novel relation between higher levels of RDW and elevated E/E' in patients with AHF. This novel finding raises the possibility that a simple marker, RDW may be associated with elevated LVFP in patients with AHF.
BACKGROUND: Red cell distribution width (RDW) has recently been discovered to be a novel prognostic marker in patients with heart failure. However, the relation between RDW and echocardiographic parameters in acute heart failure (AHF) has not been studied. METHODS AND RESULTS: We analyzed laboratory findings including RDW, N-terminal pro-brain natriuretic peptide (NT-proBNP), and echocardiographic parameters in 100 patients with AHF. The mean RDW was 14.2 +/- 2.0% and median NT-proBNP was 5183 pg/mL. The mean left ventricular ejection fraction was 33.1 +/- 14.5% and early mitral inflow velocity to early diastolic mitral annular velocity (E/E'), was 21.2 +/- 9.4. When the RDW was considered in tertile categories, the highest tertile group (> 14.5%) had higher E/E' (P < .001) and higher NT-proBNP (P = .02) than the lowest tertile group (< 13.2%). In multiple linear regression analysis, RDW was independently correlated with E/E' even after adjustment of other risk factors (beta-coefficient 0.431, P = .001). The optimal cutoff value of RDW for predicting E/E' > 15, suggesting elevated left ventricular filling pressure (LVFP) was 13.45% (area under the curve 0.633, P < .05). An additive power of RDW with NT-proBNP for predicting E/E' > 15 was found in logistic regression analysis (P = .038). CONCLUSIONS: We found a novel relation between higher levels of RDW and elevated E/E' in patients with AHF. This novel finding raises the possibility that a simple marker, RDW may be associated with elevated LVFP in patients with AHF.
Authors: Stephen A Hill; Ronald A Booth; P Lina Santaguida; Andrew Don-Wauchope; Judy A Brown; Mark Oremus; Usman Ali; Amy Bustamam; Nazmul Sohel; Robert McKelvie; Cynthia Balion; Parminder Raina Journal: Heart Fail Rev Date: 2014-08 Impact factor: 4.214
Authors: Sadeer G Al-Kindi; Chang H Kim; Stephen R Morris; Michael L Freeman; Nicholas T Funderburg; Benigno Rodriguez; Grace A McComsey; Jarrod E Dalton; Daniel I Simon; Michael M Lederman; Chris T Longenecker; David A Zidar Journal: J Acquir Immune Defic Syndr Date: 2017-03-01 Impact factor: 3.731
Authors: Vichai Senthong; Timothy Hudec; Sarah Neale; Yuping Wu; Stanley L Hazen; W H Wilson Tang Journal: Am J Cardiol Date: 2017-02-10 Impact factor: 2.778
Authors: Ronald A Booth; Stephen A Hill; Andrew Don-Wauchope; P Lina Santaguida; Mark Oremus; Robert McKelvie; Cynthia Balion; Judy A Brown; Usman Ali; Amy Bustamam; Nazmul Sohel; Parminder Raina Journal: Heart Fail Rev Date: 2014-08 Impact factor: 4.214