| Literature DB >> 19643098 |
Mohammed Filali1, Robert Lalonde.
Abstract
A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease.Entities:
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Year: 2009 PMID： 19643098 DOI： 10.1016/j.brainres.2009.07.066
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252