BACKGROUND: Recent evidence suggests that oxidative stress may play a role in myocarditis. PURPOSE: To test the hypothesis that 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone or MCI-186), a novel free radical scavenger, protects against acute experimental autoimmune myocarditis (EAM) in rats. METHODS: MCI-186 was administered intraperitoneally (1 mg/kg/day, 3 mg/kg/day or 10 mg/kg/day) in rats with EAM for three weeks. The results were compared with those from untreated rats with EAM. RESULTS: MCI-186 treatment did not affect the hemodynamics of the rats, but did reduce the severity of myocarditis when the heart weight:body weight ratio and the pathological scores were compared. There were significantly fewer myocardial interleukin-1beta-positive cells in rats with EAM treated with MCI-186 (at 3 mg/kg/day and 10 mg/kg/day) than in the untreated rats with EAM. CONCLUSION: MCI-186 ameliorated acute EAM in rats, suggesting that free radicals may be involved in the development of myocarditis.
BACKGROUND: Recent evidence suggests that oxidative stress may play a role in myocarditis. PURPOSE: To test the hypothesis that 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone or MCI-186), a novel free radical scavenger, protects against acute experimental autoimmune myocarditis (EAM) in rats. METHODS:MCI-186 was administered intraperitoneally (1 mg/kg/day, 3 mg/kg/day or 10 mg/kg/day) in rats with EAM for three weeks. The results were compared with those from untreated rats with EAM. RESULTS:MCI-186 treatment did not affect the hemodynamics of the rats, but did reduce the severity of myocarditis when the heart weight:body weight ratio and the pathological scores were compared. There were significantly fewer myocardial interleukin-1beta-positive cells in rats with EAM treated with MCI-186 (at 3 mg/kg/day and 10 mg/kg/day) than in the untreated rats with EAM. CONCLUSION:MCI-186 ameliorated acute EAM in rats, suggesting that free radicals may be involved in the development of myocarditis.
Authors: A Iwasaki; A Matsumori; T Yamada; T Shioi; W Wang; K Ono; R Nishio; M Okada; S Sasayama Journal: J Am Coll Cardiol Date: 1999-04 Impact factor: 24.094
Authors: S Ishiyama; M Hiroe; T Nishikawa; S Abe; T Shimojo; H Ito; S Ozasa; K Yamakawa; M Matsuzaki; M U Mohammed; H Nakazawa; T Kasajima; F Marumo Journal: Circulation Date: 1997-01-21 Impact factor: 29.690