| Literature DB >> 19640718 |
Kristjan S Gudmundsson1, Paul R Sebahar, Leah D'Aurora Richardson, John F Miller, Elizabeth M Turner, John G Catalano, Andrew Spaltenstein, Wendell Lawrence, Michael Thomson, Stephen Jenkinson.
Abstract
Several novel amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines were synthesized which had potent activity against HIV-1. The synthetic approaches adopted allowed for variation of the substitution pattern and resulting changes in antiviral activity are highlighted. This led to the identification of compounds with low and sub-nanomolar anti-HIV-1 activity.Entities:
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Year: 2009 PMID： 19640718 DOI： 10.1016/j.bmcl.2009.07.037
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823