| Literature DB >> 19640707 |
Nicola K Jobson1, Andrew R Crawford, Deborah Dewar, Sally L Pimlott, Andrew Sutherland.
Abstract
A stereoselective 10-step synthesis of iodophenoxy analogues of (2R,3S)-reboxetine has been developed with the aim of generating a new SPECT imaging agent for the noradrenaline transporter (NAT). In vitro testing of these compounds against various mono-amine transporters showed an ortho-iodophenoxy analogue to have excellent affinity (K(i) 8.4 nM) and good selectivity for NAT.Entities:
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Year: 2009 PMID： 19640707 DOI： 10.1016/j.bmcl.2009.07.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823