| Literature DB >> 19640592 |
Silvia Alboni1, Davide Cervia, Brendon Ross, Claudia Montanari, Alejandro Sanchez Gonzalez, Manuel Sanchez-Alavez, Maria Cecilia Garibaldi Marcondes, David De Vries, Shuei Sugama, Nicoletta Brunello, Joan Blom, Fabio Tascedda, Bruno Conti.
Abstract
The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.Entities:
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Year: 2009 PMID： 19640592 PMCID： PMC2745497 DOI： 10.1016/j.jneuroim.2009.06.016
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478