| Literature DB >> 19640237 |
Wing I Cheung1, Man Li Tse, Teresa Ngan, Jieru Lin, Ws Ken Lee, Wing Tat Poon, Tony Wl Mak, Vincent King Sun Leung, Tai Nin Chau.
Abstract
Fructus Psoraleae (FP) is used by herbalists for the treatment of postmenopausal osteoporosis, vitiligo, and psoriasis. It is used alone, or in combination with other herbs, in some countries in the form of proprietary medicine. It is recognized as one of the emerging hepatotoxins and here we report three cases of acute hepatitis after exposed to FP and its related proprietary medicine. It seems possible that psoralen and its related chemicals may be responsible for the hepatotoxicity. Decoction with other herbs may result in higher concentration of toxic constituents and in more severe liver injury. In summary, FP is associated with hepatotoxicity in some individuals. Pharmacovigilance for the potential side effects of herbal products is necessary.Entities:
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Year: 2009 PMID： 19640237 DOI： 10.1080/15563650903059136
Source DB: PubMed Journal: Clin Toxicol (Phila) ISSN： 1556-3650 Impact factor: 4.467