INTRODUCTION: There is strong evidence that high meat intake increases the risk of colorectal cancer. However, for other cancer sites there is currently less convincing evidence. METHODS: To further explore associations between meat intake and cancer risk we conducted a multisite case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. We used unconditional logistic regression to estimate odds ratios and 95% confidence intervals of cancer associated with meat intake. RESULTS: In the multivariable model there was a significant increase in the odds of cancers of the oral cavity and pharynx (OR= 3.65, 95% CI: 2.21-6.01), esophagus (OR= 3.36, 95% CI: 1.97-5.72), larynx (OR=2.91, 95% CI: 1.80-4.68), stomach (OR= 2.19, 95% CI: 1.31-3.65), colorectum (OR= 3.83, 95% CI: 2.37-6.20), lung (OR= 2.17, 95% CI: 1.52-3.10), breast (OR= 1.97, 95% CI: 1.04-3.75), prostate (OR= 1.87, 95% CI: 1.08-3.21), bladder (OR= 2.11, 95% CI: 1.20-3.72) and kidney (OR= 2.72, 95% CI: 1.22-6.07) with high intake of red meat and similar findings were found for total meat. In addition, intake of beef and lamb were also associated with increased risk of several cancer sites. High intake of processed meat was associated with increased risk of cancers of the esophagus (OR= 1.63, 95% CI: 1.08-2.47), larynx (OR= 1.84, 95% CI: 1.21-2.78), stomach (OR= 1.62, 95% CI: 1.07-2.44), colorectum (OR= 2.15, 95% CI: 1.49-3.11), lung (OR= 1.70, 95% CI: 1.28-2.25) and breast (OR= 1.53, 95% CI: 1.01-2.30). CONCLUSION: Our results confirm earlier findings of increased risk of digestive tract cancers, but suggest that meat consumption also increases the risk of several other cancers.
INTRODUCTION: There is strong evidence that high meat intake increases the risk of colorectal cancer. However, for other cancer sites there is currently less convincing evidence. METHODS: To further explore associations between meat intake and cancer risk we conducted a multisite case-control study of 11 cancer sites in Uruguay between 1996 and 2004, including 3,539 cancer cases and 2,032 hospital controls. We used unconditional logistic regression to estimate odds ratios and 95% confidence intervals of cancer associated with meat intake. RESULTS: In the multivariable model there was a significant increase in the odds of cancers of the oral cavity and pharynx (OR= 3.65, 95% CI: 2.21-6.01), esophagus (OR= 3.36, 95% CI: 1.97-5.72), larynx (OR=2.91, 95% CI: 1.80-4.68), stomach (OR= 2.19, 95% CI: 1.31-3.65), colorectum (OR= 3.83, 95% CI: 2.37-6.20), lung (OR= 2.17, 95% CI: 1.52-3.10), breast (OR= 1.97, 95% CI: 1.04-3.75), prostate (OR= 1.87, 95% CI: 1.08-3.21), bladder (OR= 2.11, 95% CI: 1.20-3.72) and kidney (OR= 2.72, 95% CI: 1.22-6.07) with high intake of red meat and similar findings were found for total meat. In addition, intake of beef and lamb were also associated with increased risk of several cancer sites. High intake of processed meat was associated with increased risk of cancers of the esophagus (OR= 1.63, 95% CI: 1.08-2.47), larynx (OR= 1.84, 95% CI: 1.21-2.78), stomach (OR= 1.62, 95% CI: 1.07-2.44), colorectum (OR= 2.15, 95% CI: 1.49-3.11), lung (OR= 1.70, 95% CI: 1.28-2.25) and breast (OR= 1.53, 95% CI: 1.01-2.30). CONCLUSION: Our results confirm earlier findings of increased risk of digestive tract cancers, but suggest that meat consumption also increases the risk of several other cancers.
Authors: W S Yang; M Y Wong; E Vogtmann; R Q Tang; L Xie; Y S Yang; Q J Wu; W Zhang; Y B Xiang Journal: Ann Oncol Date: 2012-07-31 Impact factor: 32.976
Authors: Shu-Chun Chuang; Mazda Jenab; Julia E Heck; Cristina Bosetti; Renato Talamini; Keitaro Matsuo; Xavier Castellsague; Silvia Franceschi; Rolando Herrero; Deborah M Winn; Carlo La Vecchia; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Luigino Dal Maso; Karl Kelsey; Michael D McClean; Thomas Vaughan; Philip Lazarus; Joshua Muscat; Heribert Ramroth; Chu Chen; Stephen M Schwartz; Jose Eluf-Neto; Richard B Hayes; Mark Purdue; Stefania Boccia; Gabriella Cadoni; David Zaridze; Sergio Koifman; Maria Paula Curado; Wolfgang Ahrens; Simone Benhamou; Elena Matos; Pagona Lagiou; Neonilla Szeszenia-Dabrowska; Andrew F Olshan; Leticia Fernandez; Ana Menezes; Antonio Agudo; Alexander W Daudt; Franco Merletti; Gary J Macfarlane; Kristina Kjaerheim; Dana Mates; Ivana Holcatova; Stimson Schantz; Guo-Pei Yu; Lorenzo Simonato; Hermann Brenner; Heiko Mueller; David I Conway; Peter Thomson; Eleonora Fabianova; Ariana Znaor; Peter Rudnai; Claire M Healy; Gilles Ferro; Paul Brennan; Paolo Boffetta; Mia Hashibe Journal: Cancer Causes Control Date: 2011-10-29 Impact factor: 2.506
Authors: Patricia Bonequi; Fernando Meneses-González; Pelayo Correa; Charles S Rabkin; M Constanza Camargo Journal: Cancer Causes Control Date: 2012-12-07 Impact factor: 2.506