BACKGROUND: There are few empirical studies on the valuation of health profiles that describe the short-term fluctuations of chronic diseases. OBJECTIVE: This study aimed to value chronic obstructive pulmonary disease (COPD) health profiles, which describe the health of these patients over the course of 1 year from a societal perspective. METHODS: We developed 16 COPD health profiles. Each profile combined a description of the severity of COPD during the stable phase with a description of the exacerbation profile in terms of severity, frequency and duration. These profiles were valued by a representative sample of 239 Dutch adults using the visual analogue scale (VAS) and time trade-off (TTO) methods. Value functions were estimated using random effects regression analysis. RESULTS: Both VAS and TTO values consistently decreased as severity of the COPD profiles increased. Estimated TTO values ranged from 0.97 for mild COPD without exacerbations to 0.43 for very severe COPD with one non-serious and one serious exacerbation per year. The estimated decrements in TTO values ranged from 0.010 for having one non-serious exacerbation to 0.088 for having one non-serious plus one serious exacerbation per year. CONCLUSIONS: The value function may be an alternative way to model the joint impact of COPD severity and exacerbations on utility values in health economic modelling studies.
BACKGROUND: There are few empirical studies on the valuation of health profiles that describe the short-term fluctuations of chronic diseases. OBJECTIVE: This study aimed to value chronic obstructive pulmonary disease (COPD) health profiles, which describe the health of these patients over the course of 1 year from a societal perspective. METHODS: We developed 16 COPD health profiles. Each profile combined a description of the severity of COPD during the stable phase with a description of the exacerbation profile in terms of severity, frequency and duration. These profiles were valued by a representative sample of 239 Dutch adults using the visual analogue scale (VAS) and time trade-off (TTO) methods. Value functions were estimated using random effects regression analysis. RESULTS: Both VAS and TTO values consistently decreased as severity of the COPD profiles increased. Estimated TTO values ranged from 0.97 for mild COPD without exacerbations to 0.43 for very severe COPD with one non-serious and one serious exacerbation per year. The estimated decrements in TTO values ranged from 0.010 for having one non-serious exacerbation to 0.088 for having one non-serious plus one serious exacerbation per year. CONCLUSIONS: The value function may be an alternative way to model the joint impact of COPD severity and exacerbations on utility values in health economic modelling studies.
Authors: Jan B Oostenbrink; Maureen P M H Rutten-van Mölken; Brigitta U Monz; J Mark FitzGerald Journal: Value Health Date: 2005 Jan-Feb Impact factor: 5.725
Authors: W Vincken; J A van Noord; A P M Greefhorst; Th A Bantje; S Kesten; L Korducki; P J G Cornelissen Journal: Eur Respir J Date: 2002-02 Impact factor: 16.671
Authors: Kate M Johnson; Mohsen Sadatsafavi; Amin Adibi; Larry Lynd; Mark Harrison; Hamid Tavakoli; Don D Sin; Stirling Bryan Journal: Appl Health Econ Health Policy Date: 2020-11-02 Impact factor: 2.561
Authors: K Chandra; G Blackhouse; B R McCurdy; M Bornstein; K Campbell; V Costa; J Franek; K Kaulback; L Levin; S Sehatzadeh; N Sikich; M Thabane; R Goeree Journal: Ont Health Technol Assess Ser Date: 2012-03-01
Authors: Nadine Hertel; Robert W Kotchie; Yevgeniy Samyshkin; Matthew Radford; Samantha Humphreys; Kevin Jameson Journal: Int J Chron Obstruct Pulmon Dis Date: 2012-03-19
Authors: David Price; Yumi Asukai; Jaithri Ananthapavan; Bill Malcolm; Amr Radwan; Ian Keyzor Journal: Appl Health Econ Health Policy Date: 2013-06 Impact factor: 2.561
Authors: Yevgeniy Samyshkin; Michael Schlunegger; Susan Haefliger; Sabine Ledderhose; Matthew Radford Journal: Int J Chron Obstruct Pulmon Dis Date: 2013-01-30