STUDY OBJECTIVES: We investigated basal metabolic rate (BMR) and energy expenditure (EE) in narcoleptic patients and in BMI- and age-matched controls in order to explore the hypothesis that a reduced BMR or EE plays a role in narcolepsy-associated obesity. DESIGN: Control group design with comparison of EE and BMR. EE was determined by indirect calorimetry using the Deltatrac Metabolic Monitor system. BMR was calculated from the oxygen consumption (VO2) and the carbon dioxide consumption (VCO2) measurements after 12 hours of fasting in the morning. PARTICIPANTS: 13 narcoleptic patients and 30 controls. RESULTS: BMR and EE were not significantly reduced when all subjects were included into the analysis. Subgroup analysis revealed that only non-obese narcoleptics, but not obese narcoleptics had reduced BMRs in comparison to the BMI matched controls. CONCLUSION: Our study suggests that EE plays a role in narcolepsy associated obesity. We propose that narcolepsy may lead to a shift of individual BMI set points.
STUDY OBJECTIVES: We investigated basal metabolic rate (BMR) and energy expenditure (EE) in narcolepticpatients and in BMI- and age-matched controls in order to explore the hypothesis that a reduced BMR or EE plays a role in narcolepsy-associated obesity. DESIGN: Control group design with comparison of EE and BMR. EE was determined by indirect calorimetry using the Deltatrac Metabolic Monitor system. BMR was calculated from the oxygen consumption (VO2) and the carbon dioxide consumption (VCO2) measurements after 12 hours of fasting in the morning. PARTICIPANTS: 13 narcolepticpatients and 30 controls. RESULTS: BMR and EE were not significantly reduced when all subjects were included into the analysis. Subgroup analysis revealed that only non-obese narcoleptics, but not obese narcoleptics had reduced BMRs in comparison to the BMI matched controls. CONCLUSION: Our study suggests that EE plays a role in narcolepsy associated obesity. We propose that narcolepsy may lead to a shift of individual BMI set points.
Authors: G S Metsios; A Stavropoulos-Kalinoglou; A M Nevill; K M J Douglas; Y Koutedakis; G D Kitas Journal: Ann Rheum Dis Date: 2008-01 Impact factor: 19.103
Authors: Claire E H M Donjacour; Daniel Pardi; N Ahmad Aziz; Marijke Frölich; Ferdinand Roelfsema; Sebastiaan Overeem; Hanno Pijl; Gert Jan Lammers Journal: J Clin Sleep Med Date: 2013-08-15 Impact factor: 4.062