OBJECTIVE: To evaluate the pathologic characteristics that are associated with outcomes in pT1 penile squamous cell carcinoma (SCC) treated with laser excision. STUDY DESIGN: Peniscopic magnification and 5% acetic acid application were performed prior to CO2 laser excision. Specimens were reviewed to reassess stage, grade, invasion depth, carcinoma in situ, margins, tumor extension, lymphovascular invasion and human papillomavirus infection. Association between local recurrence (LR) and prognostic factors was established with Fisher exact test, chi2 test for categorical variables and Wilcoxon rank sum test for continuous variables. RESULTS: After a median follow-up of 66 months, 53 of 56 patients were alive and disease free; 3 died of unrelated and intercurrent diseases. Thirteen had an LR, with 4 experiencing multiple recurrences and 1 needing a partial amputation. Two patients had inguinal nodal metastasis in 1 node. LR had a positive correlation with positive surgical margins and depth of invasion and a negative correlation with tumor extension. CONCLUSION: Histopathologic parameters such as margin status, depth of invasion and tumor extension are predictors of LR in T1 penile SCC treated by CO2 laser excision. A logistic model could estimate each patient's risk of LR.
OBJECTIVE: To evaluate the pathologic characteristics that are associated with outcomes in pT1penile squamous cell carcinoma (SCC) treated with laser excision. STUDY DESIGN: Peniscopic magnification and 5% acetic acid application were performed prior to CO2 laser excision. Specimens were reviewed to reassess stage, grade, invasion depth, carcinoma in situ, margins, tumor extension, lymphovascular invasion and human papillomavirus infection. Association between local recurrence (LR) and prognostic factors was established with Fisher exact test, chi2 test for categorical variables and Wilcoxon rank sum test for continuous variables. RESULTS: After a median follow-up of 66 months, 53 of 56 patients were alive and disease free; 3 died of unrelated and intercurrent diseases. Thirteen had an LR, with 4 experiencing multiple recurrences and 1 needing a partial amputation. Two patients had inguinal nodal metastasis in 1 node. LR had a positive correlation with positive surgical margins and depth of invasion and a negative correlation with tumor extension. CONCLUSION: Histopathologic parameters such as margin status, depth of invasion and tumor extension are predictors of LR in T1 penile SCC treated by CO2 laser excision. A logistic model could estimate each patient's risk of LR.
Authors: Gennaro Musi; Andrea Russo; Andrea Conti; Francesco A Mistretta; Ettore Di Trapani; Stefano Luzzago; Roberto Bianchi; Giuseppe Renne; Stefano Ramoni; Matteo Ferro; Deliu Victor Matei; Marco Cusini; Luca Carmignani; Ottavio de Cobelli Journal: World J Urol Date: 2017-12-02 Impact factor: 4.226
Authors: Juan Chipollini; Sharon Chaing; Mounsif Azizi; Laura C Kidd; Patricia Kim; Philippe E Spiess Journal: Int J Mol Sci Date: 2017-08-16 Impact factor: 5.923