PURPOSE: To establish the best technique for thoracoscopic pneumonectomy in the rat and to analyze the differences in perioperative immune response between open and video-assisted thoracoscopic surgery (VATS) in a rat model. METHODS: The four experimental groups studied were as follows: VATS pneumonectomy, open pneumonectomy, thoracoscopic observation, and open observation. We measured the immunocyte counts and serum cytokine levels postoperatively in each group. RESULTS: The CD3+, CD4+, and CD8+ lymphocyte counts were decreased significantly 12-24 h postoperatively in all groups. Immunosuppression peaked later in the open approach groups than in the VATS groups. The interleukin-6 level was significantly higher in the open approach groups than in the VATS groups. CONCLUSIONS: From the viewpoint of immunity, in this rat model VATS was less invasive than open surgery, and open surgery caused greater immunosuppression than VATS, irrespective of organ resection.
PURPOSE: To establish the best technique for thoracoscopic pneumonectomy in the rat and to analyze the differences in perioperative immune response between open and video-assisted thoracoscopic surgery (VATS) in a rat model. METHODS: The four experimental groups studied were as follows: VATS pneumonectomy, open pneumonectomy, thoracoscopic observation, and open observation. We measured the immunocyte counts and serum cytokine levels postoperatively in each group. RESULTS: The CD3+, CD4+, and CD8+ lymphocyte counts were decreased significantly 12-24 h postoperatively in all groups. Immunosuppression peaked later in the open approach groups than in the VATS groups. The interleukin-6 level was significantly higher in the open approach groups than in the VATS groups. CONCLUSIONS: From the viewpoint of immunity, in this rat model VATS was less invasive than open surgery, and open surgery caused greater immunosuppression than VATS, irrespective of organ resection.
Authors: T Tashiro; H Yamamori; K Takagi; N Hayashi; K Furukawa; H Nitta; Y Toyoda; W Sano; T Itabashi; K Nishiya; J Hirano; N Nakajima Journal: Nutrition Date: 1999-10 Impact factor: 4.008
Authors: K Ogawa; M Hirai; T Katsube; M Murayama; K Hamaguchi; T Shimakawa; Y Naritake; T Hosokawa; T Kajiwara Journal: Surgery Date: 2000-03 Impact factor: 3.982
Authors: J Bachmann; T Müller; A Schröder; C Riediger; M Feith; D Reim; H Friess; M E Martignoni Journal: Med Oncol Date: 2015-06-13 Impact factor: 3.064