| Literature DB >> 19639271 |
Jyuri Watanuki1, Kinta Hatakeyama2, Takashi Sonoki3, Hiro Tatetsu4, Katsuhiko Yoshida5, Soichiro Fujii6, Minoru Mizutani7, Toru Abo8, Miwa Kurimoto1, Hiroshi Matsuoka1, Fumihiko Matsuno4, Hideki Nakakuma1.
Abstract
We report seven large B cell lymphoma patients showing the involvement of tumor cells with cyclin D3 (CCND3) expression in bone marrow (BM) at the initial diagnosis. All patients presented with B symptoms, splenomegaly, and anemia/thrombocytopenia lacking hemophagocytosis in the BM. Five of the seven patients had suffered from immunological diseases or cancers. The tumor cells were divided into those with a lymphoplasmacytoid or blastoid appearance. Six cases were confirmed to express CD5 antigen on tumor cells. Three cases presented a chromosomal translocation between CCND3 and the immunoglobulin heavy chain (IGH) loci, t(6;14)(p21;q32). Three and two cases showed unmutated and mutated sequences of the variable region of IGH (VH), respectively, and one case showed deletion of an entire segment of VH. Two cases with t(6;14)(p21;q32) showed an unmutated VH sequence and chromosomal translocation within the switch region of IGH. Further studies are required to determine whether CCND3 expression is associated with a unique subset of diffuse large B cell lymphoma.Entities:
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Year: 2009 PMID： 19639271 DOI： 10.1007/s12185-009-0382-6
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490