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Literature DB >> 19639180

Metastatic effect of LY-6K gene in breast cancer cells.

Suh Hee Choi¹, Hyun Kyung Kong, So Young Park, Jong Hoon Park.

Abstract

The over-expression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis. As LY-6K belongs to the Ly6/uPAR superfamily, we assessed the association of LY-6K with metastasis in breast cancer cell lines and how the LY-6K gene mediates cancer cell metastasis. The migration ability of cells in which expression of LY-6K gene is up- or down-regulated was investigated by transfecting LY-6K naked DNA and treating LY-6K siRNA. Assays of wound healing, migration and invasion were performed. The assays demonstrated that cell migration significantly increased when LY-6K gene is over-expressed or LY-6K protein is abnormally expressed in breast cancer cells. In addition, LY-6K caused cancer cell metastasis and it is linked to the Ras/ERK signaling pathway. Our results suggest that LY-6K meaningfully participates in breast cancer cell metastasis by influencing cell migration and invasion through the Ras/ERK pathway.

Entities: Disease Gene

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Year: 2009 PMID： 19639180 DOI： 10.3892/ijo_00000371

Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650

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Cited

12 in total

1. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling.

Authors: Geeta Upadhyay; Yuzhi Yin; Hongyan Yuan; Xin Li; Rik Derynck; Robert I Glazer
Journal: Proc Natl Acad Sci U S A Date: 2011-04-25 Impact factor: 11.205

2. The regulatory mechanism of the LY6K gene expression in human breast cancer cells.

Authors: Hyun Kyung Kong; Sukjoon Yoon; Jong Hoon Park
Journal: J Biol Chem Date: 2012-09-17 Impact factor: 5.157

3. Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance.

Authors: Midrar AlHossiny; Linlin Luo; William R Frazier; Noriko Steiner; Yuriy Gusev; Bhaskar Kallakury; Eric Glasgow; Karen Creswell; Subha Madhavan; Rakesh Kumar; Geeta Upadhyay
Journal: Cancer Res Date: 2016-04-11 Impact factor: 12.701

4. Phase I clinical trial of vaccination with LY6K-derived peptide in patients with advanced gastric cancer.

Authors: Hajime Ishikawa; Motohiro Imano; Osamu Shiraishi; Atsushi Yasuda; Ying-Feng Peng; Masayuki Shinkai; Takushi Yasuda; Haruhiko Imamoto; Hitoshi Shiozaki
Journal: Gastric Cancer Date: 2013-04-24 Impact factor: 7.370

5. LY6K is a novel molecular target in bladder cancer on basis of integrate genome-wide profiling.

Authors: R Matsuda; H Enokida; T Chiyomaru; N Kikkawa; T Sugimoto; K Kawakami; S Tatarano; H Yoshino; K Toki; Y Uchida; K Kawahara; K Nishiyama; N Seki; M Nakagawa
Journal: Br J Cancer Date: 2010-11-09 Impact factor: 7.640

Review 6. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.

Authors: Chelsea L Loughner; Elspeth A Bruford; Monica S McAndrews; Emili E Delp; Sudha Swamynathan; Shivalingappa K Swamynathan
Journal: Hum Genomics Date: 2016-04-21 Impact factor: 4.639

7. Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome.

Authors: Linlin Luo; Peter McGarvey; Subha Madhavan; Rakesh Kumar; Yuriy Gusev; Geeta Upadhyay
Journal: Oncotarget Date: 2016-03-08