Literature DB >> 19636871

NMR assignment of Cdc42(T35A), an active Switch I mutant of Cdc42.

Paul D Adams1, Robert E Oswald.   

Abstract

Cdc42(T35A) is an active construct of Cdc42, a Ras GTPase involved in signal transduction, containing a single-point mutation in an important effector-binding region. We determined the backbone and side chain resonance assignments of (13)C,(15)N-labelled Cdc42(T35A) from E. coli.

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Year:  2007        PMID: 19636871     DOI: 10.1007/s12104-007-9062-8

Source DB:  PubMed          Journal:  Biomol NMR Assign        ISSN: 1874-270X            Impact factor:   0.746


  3 in total

1.  Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor.

Authors:  Kyla M Morris; Rory Henderson; Thallapuranam Krishnaswamy Suresh Kumar; Colin D Heyes; Paul D Adams
Journal:  Small GTPases       Date:  2016-02-01

2.  A switch I mutant of Cdc42 exhibits less conformational freedom.

Authors:  Reena Chandrashekar; Omar Salem; Hana Krizova; Robert McFeeters; Paul D Adams
Journal:  Biochemistry       Date:  2011-06-24       Impact factor: 3.162

3.  Dual modes of cdc42 recycling fine-tune polarized morphogenesis.

Authors:  Brian D Slaughter; Arupratan Das; Joel W Schwartz; Boris Rubinstein; Rong Li
Journal:  Dev Cell       Date:  2009-12       Impact factor: 12.270

  3 in total

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