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Literature DB >> 19636343

Systems genetics analysis of cancer susceptibility: from mouse models to humans.

Abstract

Genetic studies of cancer susceptibility have shown that most heritable risk cannot be explained by the main effects of common alleles. This may be due to unknown gene-gene or gene-environment interactions and the complex roles of many genes at different stages of cancer. Studies using mouse models of cancer suggest that methods that integrate genetic analysis and genomic networks with knowledge of cancer biology can help to extend our understanding of heritable cancer susceptibility.

Entities: Disease Species

Mesh：

Year: 2009 PMID： 19636343 DOI： 10.1038/nrg2617

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

58 in total

Review 1. Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.

Authors: Nicola S Fearnhead; Bruce Winney; Walter F Bodmer
Journal: Cell Cycle Date: 2005-04-07 Impact factor: 4.534

2. An integrative genomics approach to infer causal associations between gene expression and disease.

Authors: Eric E Schadt; John Lamb; Xia Yang; Jun Zhu; Steve Edwards; Debraj Guhathakurta; Solveig K Sieberts; Stephanie Monks; Marc Reitman; Chunsheng Zhang; Pek Yee Lum; Amy Leonardson; Rolf Thieringer; Joseph M Metzger; Liming Yang; John Castle; Haoyuan Zhu; Shera F Kash; Thomas A Drake; Alan Sachs; Aldons J Lusis
Journal: Nat Genet Date: 2005-06-19 Impact factor: 38.330

3. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.

Authors: Minh D To; Jesus Perez-Losada; Jian-Hua Mao; Jeff Hsu; Tyler Jacks; Allan Balmain
Journal: Nat Genet Date: 2006-07-02 Impact factor: 38.330

4. Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians.

Authors: Jian Gu; Yubo Gong; Maosheng Huang; Charles Lu; Margaret R Spitz; Xifeng Wu
Journal: Carcinogenesis Date: 2006-08-21 Impact factor: 4.944

5. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.

Authors: Jian-Hua Mao; Jesus Perez-Losada; Di Wu; Reyno Delrosario; Ryosuke Tsunematsu; Keiichi I Nakayama; Ken Brown; Sheila Bryson; Allan Balmain
Journal: Nature Date: 2004-12-09 Impact factor: 49.962

6. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.

Authors: Jian-Hua Mao; Elise F Saunier; John P de Koning; Margaret M McKinnon; Mamie Nakijama Higgins; Kathy Nicklas; Hai-Tao Yang; Allan Balmain; Rosemary J Akhurst
Journal: Proc Natl Acad Sci U S A Date: 2006-05-15 Impact factor: 11.205

Review 7. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer.

Authors: Lecia V Sequist; Daphne W Bell; Thomas J Lynch; Daniel A Haber
Journal: J Clin Oncol Date: 2007-02-10 Impact factor: 44.544

8. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.

Authors: Jian-Hua Mao; Di Wu; Jesus Perez-Losada; Tao Jiang; Qian Li; Richard M Neve; Joe W Gray; Wei-Wen Cai; Allan Balmain
Journal: Cancer Cell Date: 2007-02 Impact factor: 31.743

9. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.

Authors: M MacPhee; K P Chepenik; R A Liddell; K K Nelson; L D Siracusa; A M Buchberg
Journal: Cell Date: 1995-06-16 Impact factor: 41.582

10. Genome-wide association study identifies novel breast cancer susceptibility loci.

Authors: Douglas F Easton; Karen A Pooley; Alison M Dunning; Paul D P Pharoah; Deborah Thompson; Dennis G Ballinger; Jeffery P Struewing; Jonathan Morrison; Helen Field; Robert Luben; Nicholas Wareham; Shahana Ahmed; Catherine S Healey; Richard Bowman; Kerstin B Meyer; Christopher A Haiman; Laurence K Kolonel; Brian E Henderson; Loic Le Marchand; Paul Brennan; Suleeporn Sangrajrang; Valerie Gaborieau; Fabrice Odefrey; Chen-Yang Shen; Pei-Ei Wu; Hui-Chun Wang; Diana Eccles; D Gareth Evans; Julian Peto; Olivia Fletcher; Nichola Johnson; Sheila Seal; Michael R Stratton; Nazneen Rahman; Georgia Chenevix-Trench; Stig E Bojesen; Børge G Nordestgaard; Christen K Axelsson; Montserrat Garcia-Closas; Louise Brinton; Stephen Chanock; Jolanta Lissowska; Beata Peplonska; Heli Nevanlinna; Rainer Fagerholm; Hannaleena Eerola; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; David J Hunter; Susan E Hankinson; David G Cox; Per Hall; Sara Wedren; Jianjun Liu; Yen-Ling Low; Natalia Bogdanova; Peter Schürmann; Thilo Dörk; Rob A E M Tollenaar; Catharina E Jacobi; Peter Devilee; Jan G M Klijn; Alice J Sigurdson; Michele M Doody; Bruce H Alexander; Jinghui Zhang; Angela Cox; Ian W Brock; Gordon MacPherson; Malcolm W R Reed; Fergus J Couch; Ellen L Goode; Janet E Olson; Hanne Meijers-Heijboer; Ans van den Ouweland; André Uitterlinden; Fernando Rivadeneira; Roger L Milne; Gloria Ribas; Anna Gonzalez-Neira; Javier Benitez; John L Hopper; Margaret McCredie; Melissa Southey; Graham G Giles; Chris Schroen; Christina Justenhoven; Hiltrud Brauch; Ute Hamann; Yon-Dschun Ko; Amanda B Spurdle; Jonathan Beesley; Xiaoqing Chen; Arto Mannermaa; Veli-Matti Kosma; Vesa Kataja; Jaana Hartikainen; Nicholas E Day; David R Cox; Bruce A J Ponder
Journal: Nature Date: 2007-06-28 Impact factor: 49.962

24 in total

Review 1. Cancer evolution and individual susceptibility.

Authors: Jesús Pérez-Losada; Andrés Castellanos-Martín; Jian-Hua Mao
Journal: Integr Biol (Camb) Date: 2011-01-24 Impact factor: 2.192

Review 2. Principles and methods of integrative genomic analyses in cancer.

Authors: Vessela N Kristensen; Ole Christian Lingjærde; Hege G Russnes; Hans Kristian M Vollan; Arnoldo Frigessi; Anne-Lise Børresen-Dale
Journal: Nat Rev Cancer Date: 2014-05 Impact factor: 60.716

3. Multiscale analysis of the murine intestine for modeling human diseases.

Authors: Jesse Lyons; Charles A Herring; Amrita Banerjee; Alan J Simmons; Ken S Lau
Journal: Integr Biol (Camb) Date: 2015-07 Impact factor: 2.192

4. Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network.

Authors: Jieqing Zhu; Gaofeng Xiong; Hanjiang Fu; B Mark Evers; Binhua P Zhou; Ren Xu
Journal: Cancer Res Date: 2015-03-05 Impact factor: 12.701

5. The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.

Authors: David A Quigley; Elisa Fiorito; Silje Nord; Peter Van Loo; Grethe Grenaker Alnæs; Thomas Fleischer; Jorg Tost; Hans Kristian Moen Vollan; Trine Tramm; Jens Overgaard; Ida R Bukholm; Antoni Hurtado; Allan Balmain; Anne-Lise Børresen-Dale; Vessela Kristensen
Journal: Mol Oncol Date: 2013-12-03 Impact factor: 6.603

6. A genetic ensemble approach for gene-gene interaction identification.

Authors: Pengyi Yang; Joshua W K Ho; Albert Y Zomaya; Bing B Zhou
Journal: BMC Bioinformatics Date: 2010-10-21 Impact factor: 3.169

Review 7. Systems genetics approaches to understand complex traits.

Authors: Mete Civelek; Aldons J Lusis
Journal: Nat Rev Genet Date: 2013-12-03 Impact factor: 53.242

8. Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma.

Authors: Devin G Roller; Mark Axelrod; Brian J Capaldo; Karin Jensen; Aaron Mackey; Michael J Weber; Daniel Gioeli
Journal: Mol Cancer Ther Date: 2012-09-07 Impact factor: 6.261

Review 9. Neuroblastoma: developmental biology, cancer genomics and immunotherapy.

Authors: Nai-Kong V Cheung; Michael A Dyer
Journal: Nat Rev Cancer Date: 2013-06 Impact factor: 60.716

10. Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression.

Authors: B Ferguson; R Ram; H Y Handoko; P Mukhopadhyay; H K Muller; H P Soyer; G Morahan; G J Walker
Journal: Oncogene Date: 2014-08-04 Impact factor: 9.867