Literature DB >> 19636307

Who will take up the gauntlet? Challenges and opportunities for systems biology and drug discovery.

Adriano M Henney1.   

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Year:  2009        PMID： 19636307      PMCID： PMC2725997          DOI： 10.1038/embor.2009.132

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


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  13 in total

1.  Navigating the evolving world of drug discovery.

Authors: 
Journal:  Nat Rev Drug Discov       Date:  2002-01       Impact factor: 84.694

2.  A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-08       Impact factor: 5.182

3.  The impact of systems approaches on biological problems in drug discovery.

Authors:  Leroy Hood; Roger M Perlmutter
Journal:  Nat Biotechnol       Date:  2004-10       Impact factor: 54.908

4.  Application of predictive biosimulation within pharmaceutical clinical development: examples of significance for translational medicine and clinical trial design.

Authors:  A R Kansal; J Trimmer
Journal:  Syst Biol (Stevenage)       Date:  2005-12

5.  Predictive biosimulation and virtual patients in pharmaceutical R and D.

Authors:  Alex Bangs
Journal:  Stud Health Technol Inform       Date:  2005

6.  A network solution.

Authors:  Adriano Henney; Giulio Superti-Furga
Journal:  Nature       Date:  2008-10-09       Impact factor: 49.962

7.  Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib.

Authors:  B S Hendriks; G J Griffiths; R Benson; D Kenyon; M Lazzara; J Swinton; S Beck; M Hickinson; J M Beusmans; D Lauffenburger; D de Graaf
Journal:  Syst Biol (Stevenage)       Date:  2006-11

8.  Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity.

Authors:  B S Hendriks; J Cook; J M Burke; J M Beusmans; D A Lauffenburger; D de Graaf
Journal:  Syst Biol (Stevenage)       Date:  2006-01

9.  EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Authors:  J Guillermo Paez; Pasi A Jänne; Jeffrey C Lee; Sean Tracy; Heidi Greulich; Stacey Gabriel; Paula Herman; Frederic J Kaye; Neal Lindeman; Titus J Boggon; Katsuhiko Naoki; Hidefumi Sasaki; Yoshitaka Fujii; Michael J Eck; William R Sellers; Bruce E Johnson; Matthew Meyerson
Journal:  Science       Date:  2004-04-29       Impact factor: 47.728

10.  Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

Authors:  Thomas J Lynch; Daphne W Bell; Raffaella Sordella; Sarada Gurubhagavatula; Ross A Okimoto; Brian W Brannigan; Patricia L Harris; Sara M Haserlat; Jeffrey G Supko; Frank G Haluska; David N Louis; David C Christiani; Jeff Settleman; Daniel A Haber
Journal:  N Engl J Med       Date:  2004-04-29       Impact factor: 91.245
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  2 in total

1.  Platelet aggregation pathway network-based approach for evaluating compounds efficacy.

Authors:  Jiangyong Gu; Qian Li; Lirong Chen; Youyong Li; Tingjun Hou; Gu Yuan; Xiaojie Xu
Journal:  Evid Based Complement Alternat Med       Date:  2013-04-04       Impact factor: 2.629

2.  Strategies for structuring interdisciplinary education in Systems Biology: an European perspective.

Authors:  Marija Cvijovic; Thomas Höfer; Jure Aćimović; Lilia Alberghina; Eivind Almaas; Daniela Besozzi; Anders Blomberg; Till Bretschneider; Marta Cascante; Olivier Collin; Pedro de Atauri; Cornelia Depner; Robert Dickinson; Maciej Dobrzynski; Christian Fleck; Jordi Garcia-Ojalvo; Didier Gonze; Jens Hahn; Heide Marie Hess; Susanne Hollmann; Marcus Krantz; Ursula Kummer; Torbjörn Lundh; Gifta Martial; Vítor Martins Dos Santos; Angela Mauer-Oberthür; Babette Regierer; Barbara Skene; Egils Stalidzans; Jörg Stelling; Bas Teusink; Christopher T Workman; Stefan Hohmann
Journal:  NPJ Syst Biol Appl       Date:  2016-05-26
  2 in total

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