| Literature DB >> 19635666 |
Yun-Long Li1, Eric Shi, David Burns, Yanlong Li, Maryanne B Covington, Maxwell Pan, Peggy Scherle, Steve Friedman, Brian Metcalf, Wenqing Yao.
Abstract
A novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety, which was conventionally believed to be exposed to solvent.Entities:
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Year: 2009 PMID： 19635666 DOI： 10.1016/j.bmcl.2009.07.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823