AIM OF THE STUDY: Since ancient times, practicians of traditional Chinese medicine have discovered that Artemisia sphaerocephala Krasch. (Asteraceae) seed powder was useful for the treatment of diabetes. Artemisia sphaerocephala Krasch. gum (ASK gum), which is extracted from seed powder of the plant, is a novel food additive favored by the food industry in China. The objective of this study was to determine the antidiabetic function of ASK gum on type 2 diabetes. MATERIALS AND METHODS: Type 2 diabetic rat model was induced with high fat diet and low dose of streptozotocin (STZ). The effects of ASK gum on hyperglycemia, hyperlipemia, insulin resistance, and liver fat accumulation in type 2 diabetic rats were evaluated. The results were compared to those of normal rats and diabetic rats treated with metformin. RESULTS: The addition of ASK gum to the rats' food supply significantly lowered fasting blood glucose, glycated serum protein, serum cholesterol, and serum triglyceride in type 2 diabetic rats, and significantly elevated liver glucokinase, liver glycogen, and serum high density protein cholesterol in the diabetic rats. ASK gum significantly reduced insulin resistance and liver fat accumulation of type 2 diabetes. CONCLUSION: Artemisia sphaerocephala Krasch. gum can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes.
AIM OF THE STUDY: Since ancient times, practicians of traditional Chinese medicine have discovered that Artemisia sphaerocephala Krasch. (Asteraceae) seed powder was useful for the treatment of diabetes. Artemisia sphaerocephala Krasch. gum (ASK gum), which is extracted from seed powder of the plant, is a novel food additive favored by the food industry in China. The objective of this study was to determine the antidiabetic function of ASK gum on type 2 diabetes. MATERIALS AND METHODS: Type 2 diabeticrat model was induced with high fat diet and low dose of streptozotocin (STZ). The effects of ASK gum on hyperglycemia, hyperlipemia, insulin resistance, and liver fat accumulation in type 2 diabeticrats were evaluated. The results were compared to those of normal rats and diabeticrats treated with metformin. RESULTS: The addition of ASK gum to the rats' food supply significantly lowered fasting blood glucose, glycated serum protein, serum cholesterol, and serum triglyceride in type 2 diabeticrats, and significantly elevated liver glucokinase, liver glycogen, and serum high density protein cholesterol in the diabeticrats. ASK gum significantly reduced insulin resistance and liver fat accumulation of type 2 diabetes. CONCLUSION:Artemisia sphaerocephala Krasch. gum can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes.
Authors: Allison J Richard; Thomas P Burris; David Sanchez-Infantes; Yongjun Wang; David M Ribnicky; Jacqueline M Stephens Journal: Nutrition Date: 2014-03-12 Impact factor: 4.008
Authors: Allison J Richard; Scott Fuller; Veaceslav Fedorcenco; Robbie Beyl; Thomas P Burris; Randall Mynatt; David M Ribnicky; Jacqueline M Stephens Journal: PLoS One Date: 2014-06-10 Impact factor: 3.240