| Literature DB >> 19635502 |
Pattaraporn Sasivimolphan1, Vimolmas Lipipun, Kittisak Likhitwitayawuid, Masaya Takemoto, Pornpen Pramyothin, Masao Hattori, Kimiyasu Shiraki.
Abstract
The anti-herpes simplex virus (HSV) compound, oxyresveratrol, purified from a Thai traditional medicinal plant of Artocarpus lakoocha, was evaluated for its anti-varicella-zoster virus (VZV) activity. This compound exhibited IC(50) values (50%-inhibitory concentrations for virus plaque formation) of 12.82, 12.80, 12.99 and 12.82 microg/ml against wild type, thymidine kinase-deficient and two types of DNA polymerase mutants with acyclovir-resistance, respectively. Thus oxyresveratrol showed a broad spectrum of anti-VZV activity with a mechanism of action different from that of acyclovir.Entities:
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Year: 2009 PMID： 19635502 DOI： 10.1016/j.antiviral.2009.07.010
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970