PURPOSE: The aim of the study was to describe the changes in colonic motility occurring after chronic antegrade enema use in children and young adults. METHODS: Colonic manometry tracings of patients who had used antegrade enemas for at least 6 months and were being evaluated for possible discontinuation of this treatment were retrospective reviewed. RESULTS: Seven patients (median age of 12 years, range 3-15 years) met our inclusion criteria. Four patients had idiopathic constipation, 2 had tethered cord, and 1 had Hirschsprung disease. Colonic manometry before the use of antegrade enemas showed dysmotility in 6 (86%) children, mostly in the distal colon. None of the patients underwent colonic resection between the 2 studies. All the patients had colonic manometry repeated between 14 and 46 months after the creation of the cecostomy. All patients with abnormal colonic manometry improved with the use of antegrade enema with a complete normalization of colonic motility in 5 (83%) patients. CONCLUSION: Use of antegrade enema alone, without diversion or resection, may improve colonic motility.
PURPOSE: The aim of the study was to describe the changes in colonic motility occurring after chronic antegrade enema use in children and young adults. METHODS:Colonic manometry tracings of patients who had used antegrade enemas for at least 6 months and were being evaluated for possible discontinuation of this treatment were retrospective reviewed. RESULTS: Seven patients (median age of 12 years, range 3-15 years) met our inclusion criteria. Four patients had idiopathic constipation, 2 had tethered cord, and 1 had Hirschsprung disease. Colonic manometry before the use of antegrade enemas showed dysmotility in 6 (86%) children, mostly in the distal colon. None of the patients underwent colonic resection between the 2 studies. All the patients had colonic manometry repeated between 14 and 46 months after the creation of the cecostomy. All patients with abnormal colonic manometry improved with the use of antegrade enema with a complete normalization of colonic motility in 5 (83%) patients. CONCLUSION: Use of antegrade enema alone, without diversion or resection, may improve colonic motility.
Authors: Pernilla Stenström; Christina Granéli; Martin Salö; Kristine Hagelsteen; Einar Arnbjörnsson Journal: Biomed Res Int Date: 2013-09-23 Impact factor: 3.411
Authors: Maura Corsetti; Marcello Costa; Gabrio Bassotti; Adil E Bharucha; Osvaldo Borrelli; Phil Dinning; Carlo Di Lorenzo; Jan D Huizinga; Marcel Jimenez; Satish Rao; Robin Spiller; Nick J Spencer; Roger Lentle; Jasper Pannemans; Alexander Thys; Marc Benninga; Jan Tack Journal: Nat Rev Gastroenterol Hepatol Date: 2019-07-11 Impact factor: 46.802