Literature DB >> 19635053

Convenient synthesis of Ibuprofen and naproxen aminoacyl, dipeptidoyl and ester derivatives.

Alan R Katritzky1, Davit Jishkariani, Tamari Narindoshvili.   

Abstract

DL-Ibuprofen and L-naproxen were coupled with amino acids and other bioactive compounds to provide ibuprofen and naproxen bioconjugates in 61-95% yield as prodrugs or potential drug candidates.

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Year:  2009        PMID： 19635053     DOI： 10.1111/j.1747-0285.2009.00811.x

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  3 in total

1.  Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity.

Authors:  Rachel A Jones Lipinski; Yann Thillier; Christophe Morisseau; Christopher S Sebastiano; Brian C Smith; C Dennis Hall; Alan R Katritzky
Journal:  Chem Biol Drug Des       Date:  2021-05-28       Impact factor: 2.817

2.  Anti-inflammatory agents of the carbamoylmethyl ester class: synthesis, characterization, and pharmacological evaluation.

Authors:  Bassem Sadek; Amar Mansuor Hamruoni; Abdu Adem
Journal:  J Inflamm Res       Date:  2013-03-03

3.  Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs.

Authors:  Wenhao Xu; Jinli Yang; Xiangyang Gu; Wenjing Su; Faxiang Pu; Zhangfu Xie; Kongliang Jin; Weike Su; Lichan Mao
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.419
  3 in total

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