| Literature DB >> 19634325 |
Oscar R Suárez-Castillo1, Myriam Meléndez-Rodríguez, Yaneth M A Contreras-Martínez, Alejandro Alvarez-Hernández, Martha S Morales-Ríos, Pedro Joseph-Nathan.
Abstract
A highly efficient method for the formal synthesis of the natural product (+/-)-coerulescine 1 from tetrahydro-beta-carboline 3, mediated by dimethyldioxirane (DMD), is described. Compound 15, the N9-demethylated precursor of 1, was prepared from 3 in 4 steps with an overall yield of 95%. The effect of electron withdrawing groups at the N2,N9 atoms of 3 was explored for the oxidative rearrangement step.Entities:
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Year: 2009 PMID： 19634325
Source DB: PubMed Journal: Nat Prod Commun ISSN： 1555-9475 Impact factor: 0.986