Literature DB >> 19633582

LTD induction suppresses LTP-induced hippocampal adult neurogenesis.

Sung Kun Chun1, Woong Sun, Min Whan Jung.   

Abstract

Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis.

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Year:  2009        PMID： 19633582     DOI： 10.1097/WNR.0b013e3283303794

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  5 in total

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3.  The coexpression of reelin and neuronal nitric oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler mice.

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4.  Activation of latent precursors in the hippocampus is dependent on long-term potentiation.

Authors:  M Kameda; C J Taylor; T L Walker; D M Black; W C Abraham; P F Bartlett
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Review 5.  Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior.

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  5 in total

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