Literature DB >> 19632834

Thiazole analog as stearoyl-CoA desaturase 1 inhibitor.

Chun Sing Li1, Liette Belair, Jocelyne Guay, Renata Murgasva, Wayne Sturkenboom, Yeeman K Ramtohul, Lei Zhang, Zheng Huang.   

Abstract

SCD1 inhibition may represent a novel treatment for obesity, type-2 diabetes and related metabolic disorders. A prototype thiazole amide analog 13 (MF-152) was identified as an excellent tool in the study of SCD biology in animals.

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Year:  2009        PMID： 19632834     DOI： 10.1016/j.bmcl.2009.07.015

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors.

Authors:  France Landry; Chi-Chung Chan; Zheng Huang; Gregoire Leclair; Chun Sing Li; Renata Oballa; Lei Zhang; Kevin Bateman
Journal:  J Lipid Res       Date:  2011-06-05       Impact factor: 5.922

2.  Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes.

Authors:  Elizabeth Manickam; Andrew J Sinclair; David Cameron-Smith
Journal:  Lipids Health Dis       Date:  2010-06-04       Impact factor: 3.876

3.  Hepatic gene expression profiling reveals key pathways involved in leptin-mediated weight loss in ob/ob mice.

Authors:  Ashok Sharma; Shoshana M Bartell; Clifton A Baile; Bo Chen; Robert H Podolsky; Richard A McIndoe; Jin-Xiong She
Journal:  PLoS One       Date:  2010-08-16       Impact factor: 3.240

4.  Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.

Authors:  Christina A von Roemeling; Laura A Marlow; Johnny J Wei; Simon J Cooper; Thomas R Caulfield; Kevin Wu; Winston W Tan; Han W Tun; John A Copland
Journal:  Clin Cancer Res       Date:  2013-04-30       Impact factor: 12.531

5.  Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.

Authors:  Kristofer Thörn; Meri Hovsepyan; Peter Bergsten
Journal:  Lipids Health Dis       Date:  2010-09-29       Impact factor: 3.876
  5 in total

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