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Literature DB >> 19632186

SnapShot: BCL-2 proteins.

J Marie Hardwick¹, Richard J Youle.

Abstract

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19632186 PMCID： PMC2902885 DOI： 10.1016/j.cell.2009.07.003

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

× No keyword cloud information.

10 in total

1. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

Authors: Anthony Letai; Michael C Bassik; Loren D Walensky; Mia D Sorcinelli; Solly Weiler; Stanley J Korsmeyer
Journal: Cancer Cell Date: 2002-09 Impact factor: 31.743

2. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

Authors: Ravi Jagasia; Phillip Grote; Benedikt Westermann; Barbara Conradt
Journal: Nature Date: 2005-02-17 Impact factor: 49.962

3. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

Authors: Tomomi Kuwana; Mason R Mackey; Guy Perkins; Mark H Ellisman; Martin Latterich; Roger Schneiter; Douglas R Green; Donald D Newmeyer
Journal: Cell Date: 2002-11-01 Impact factor: 41.582

4. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death.

Authors: M O Hengartner; R E Ellis; H R Horvitz
Journal: Nature Date: 1992-04-09 Impact factor: 49.962

5. Conversion of Bcl-2 to a Bax-like death effector by caspases.

Authors: E H Cheng; D G Kirsch; R J Clem; R Ravi; M B Kastan; A Bedi; K Ueno; J M Hardwick
Journal: Science Date: 1997-12-12 Impact factor: 47.728

6. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

Authors: S Frank; B Gaume; E S Bergmann-Leitner; W W Leitner; E G Robert; F Catez; C L Smith; R J Youle
Journal: Dev Cell Date: 2001-10 Impact factor: 12.270

7. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.

Authors: D L Vaux; S Cory; J M Adams
Journal: Nature Date: 1988-09-29 Impact factor: 49.962

8. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

Authors: H Li; H Zhu; C J Xu; J Yuan
Journal: Cell Date: 1998-08-21 Impact factor: 41.582

9. The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.

Authors: Kathleen A Galindo; Wan-Jin Lu; Jae H Park; John M Abrams
Journal: Development Date: 2008-12-15 Impact factor: 6.868

Review 10. Bcl-2-regulated apoptosis: mechanism and therapeutic potential.

Authors: Jerry M Adams; Suzanne Cory
Journal: Curr Opin Immunol Date: 2007-07-12 Impact factor: 7.486

10 in total

42 in total

1. BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax.

Authors: F Wilfling; A Weber; S Potthoff; F-N Vögtle; C Meisinger; S A Paschen; G Häcker
Journal: Cell Death Differ Date: 2012-02-17 Impact factor: 15.828

2. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.

Authors: Lixia Zhao; Feng He; Haiyang Liu; Yushan Zhu; Weili Tian; Ping Gao; Hongping He; Wen Yue; Xiaobo Lei; Biyun Ni; Xiaohui Wang; Haijing Jin; Xiaojiang Hao; Jialing Lin; Quan Chen
Journal: J Biol Chem Date: 2011-11-07 Impact factor: 5.157

SnapShot: BCL-2 proteins.

1. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

2. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

3. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

4. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death.

5. Conversion of Bcl-2 to a Bax-like death effector by caspases.

6. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

7. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.

8. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

9. The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.

Review 10. Bcl-2-regulated apoptosis: mechanism and therapeutic potential.

1. BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax.

2. Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.

3. tBid undergoes multiple conformational changes at the membrane required for Bax activation.

4. Isolation and functional analysis of mitochondria from cultured cells and mouse tissue.

Review 5. Noxa in rheumatic diseases: present understanding and future impact.

6. Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation.

7. Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression.

8. Reconstitution and engineering of apoptotic protein interactions on the bacterial cell surface.

9. Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress.

10. Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis.