Wenlong Li1, Jing Xu, Xiaojian Wang, Jingzhou Chen, Channa Zhang, Kai Sun, Rutai Hui. 1. Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education & Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Abstract
OBJECTIVE: Previous case-control studies suggested the single nucleotide polymorphism of cyclooxygenase-2 (COX-2) gene (G-765C) is associated with coronary artery disease (CAD) and ischemic stroke. However, other studies did not confirm this relationship. The objective was to assess the relationship of COX-2 G-765C and CAD and ischemic stroke, using a meta-analysis. METHODS: Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. RESULTS: The meta-analysis included 4930 CAD patients and 17,997 controls, as well as 1628 ischemic stroke patients and 17,653 controls. For CAD, the pooled OR of -765C was 0.80 (95%CI: 0.65-0.98) compared to wild type allele in recessive model, and was 0.99 (95%CI: 0.92-1.06) in dominant model. For ischemic stroke, the pooled OR of -765C was 1.11 (95%CI: 0.88-1.42) in recessive model compared to wild type allele, and was 1.05 (95%CI: 0.93-1.18) in dominant model. No publication bias was found in this meta-analysis. CONCLUSION: The synthesis of available evidence supports that the COX-2 G-765C is protective for CAD. However, it is not associated with ischemic stroke.
OBJECTIVE: Previous case-control studies suggested the single nucleotide polymorphism of cyclooxygenase-2 (COX-2) gene (G-765C) is associated with coronary artery disease (CAD) and ischemic stroke. However, other studies did not confirm this relationship. The objective was to assess the relationship of COX-2G-765C and CAD and ischemic stroke, using a meta-analysis. METHODS: Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. RESULTS: The meta-analysis included 4930 CAD patients and 17,997 controls, as well as 1628 ischemic strokepatients and 17,653 controls. For CAD, the pooled OR of -765C was 0.80 (95%CI: 0.65-0.98) compared to wild type allele in recessive model, and was 0.99 (95%CI: 0.92-1.06) in dominant model. For ischemic stroke, the pooled OR of -765C was 1.11 (95%CI: 0.88-1.42) in recessive model compared to wild type allele, and was 1.05 (95%CI: 0.93-1.18) in dominant model. No publication bias was found in this meta-analysis. CONCLUSION: The synthesis of available evidence supports that the COX-2G-765C is protective for CAD. However, it is not associated with ischemic stroke.
Authors: In Jai Kim; Sang Hoon Kim; Dong Hoon Cha; Sang Wook Lim; Jae Youn Moon; Jung Oh Kim; Chang Soo Ryu; Han Sung Park; Jung Hoon Sung; Nam Keun Kim Journal: Genes Genomics Date: 2019-06-05 Impact factor: 1.839
Authors: Jamary Oliveira-Filho; Ana C P Ornellas; Cathy R Zhang; Luciana M B Oliveira; Théo Araújo-Santos; Valeria M Borges; Laís M G B Ventura; Francisco J F B Reis; Roque Aras; André M Fernandes; Jonathan Rosand; Steven M Greenberg; Karen L Furie; Natalia S Rost Journal: J Stroke Cerebrovasc Dis Date: 2015-05-06 Impact factor: 2.136