Arthur M Baker1, Richard L Klein, Kevin L Moss, Sina Haeri, Kim Boggess. 1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7516, USA. abaker2@med.unc.edu
Abstract
OBJECTIVE: We sought to determine whether serum lipids at midgestation differ between normotensive women and women developing mild and severe preeclampsia. STUDY DESIGN: A case-control study of 50 women with preeclampsia (mild = 26; severe = 24) and 100 women with uncomplicated term deliveries was conducted. Maternal serum collected at 15-20 weeks was used to measure lipid profiles. RESULTS: The groups were similar with respect to demographic characteristics. Women with mild preeclampsia had higher triglyceride levels and a higher total cholesterol to high-density lipoprotein ratio than control subjects (200 +/- 79.5 mg/dL vs 164 +/- 56.2 mg/dL; P = .02; and 3.31 +/- 1.06 mg/dL vs 2.91 +/- 0.59; P = .02). Women with severe preeclampsia had lower levels of low-density lipoprotein than control subjects (85.5 +/- 21.3 mg/dL vs 102 +/- 30.0 mg/dL; P = .04) and a less atherogenic lipid profile than control subjects. CONCLUSION: Midgestation dyslipidemia is associated with mild but not severe preeclampsia. These findings may aid in elucidating the different pathologic processes between mild and severe preeclampsia.
OBJECTIVE: We sought to determine whether serum lipids at midgestation differ between normotensive women and women developing mild and severe preeclampsia. STUDY DESIGN: A case-control study of 50 women with preeclampsia (mild = 26; severe = 24) and 100 women with uncomplicated term deliveries was conducted. Maternal serum collected at 15-20 weeks was used to measure lipid profiles. RESULTS: The groups were similar with respect to demographic characteristics. Women with mild preeclampsia had higher triglyceride levels and a higher total cholesterol to high-density lipoprotein ratio than control subjects (200 +/- 79.5 mg/dL vs 164 +/- 56.2 mg/dL; P = .02; and 3.31 +/- 1.06 mg/dL vs 2.91 +/- 0.59; P = .02). Women with severe preeclampsia had lower levels of low-density lipoprotein than control subjects (85.5 +/- 21.3 mg/dL vs 102 +/- 30.0 mg/dL; P = .04) and a less atherogenic lipid profile than control subjects. CONCLUSION:Midgestation dyslipidemia is associated with mild but not severe preeclampsia. These findings may aid in elucidating the different pathologic processes between mild and severe preeclampsia.
Authors: Carlos A Labarrere; Hector L DiCarlo; Elaine Bammerlin; James W Hardin; Yeon M Kim; Piya Chaemsaithong; David M Haas; Ghassan S Kassab; Roberto Romero Journal: Am J Obstet Gynecol Date: 2016-12-27 Impact factor: 8.661
Authors: Anne P Starling; Stephanie M Engel; Kristina W Whitworth; David B Richardson; Alison M Stuebe; Julie L Daniels; Line Småstuen Haug; Merete Eggesbø; Georg Becher; Azemira Sabaredzovic; Cathrine Thomsen; Ralph E Wilson; Gregory S Travlos; Jane A Hoppin; Donna D Baird; Matthew P Longnecker Journal: Environ Int Date: 2013-11-02 Impact factor: 9.621