Literature DB >> 19631721

RNA-mediated pathogenesis in fragile X-associated disorders.

Huiping Tan1, He Li, Peng Jin.   

Abstract

Noncoding RNAs play important and diverse regulatory roles throughout the genome and make major contributions to disease pathogenesis. The FMR1 gene is involved in three different syndromes: fragile X syndrome (FXS), primary ovarian insufficiency (POI), and fragile X-associated tremor/ataxia syndrome (FXTAS) in older patients. Noncoding RNAs have been implicated in the molecular pathogenesis of both FXS and FXTAS. Here we will review our current knowledge on the role(s) of noncoding RNAs in FXS and FXTAS, particularly the role of the microRNA pathway in FXS and the role of noncoding riboCGG (rCGG) repeat in FXTAS.

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Year:  2009        PMID： 19631721      PMCID： PMC2767401          DOI： 10.1016/j.neulet.2009.07.053

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  65 in total

1.  Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome.

Authors:  F Tassone; R J Hagerman; A K Taylor; L W Gane; T E Godfrey; P J Hagerman
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

2.  A microdeletion of less than 250 kb, including the proximal part of the FMR-I gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome.

Authors:  D Wöhrle; D Kotzot; M C Hirst; A Manca; B Korn; A Schmidt; G Barbi; H D Rott; A Poustka; K E Davies
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

3.  Abnormal development of dendritic spines in FMR1 knock-out mice.

Authors:  E A Nimchinsky; A M Oberlander; K Svoboda
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

4.  Evidence that fragile X mental retardation protein is a negative regulator of translation.

Authors:  B Laggerbauer; D Ostareck; E M Keidel; A Ostareck-Lederer; U Fischer
Journal:  Hum Mol Genet       Date:  2001-02-15       Impact factor: 6.150

5.  Translational suppression by trinucleotide repeat expansion at FMR1.

Authors:  Y Feng; F Zhang; L K Lokey; J L Chastain; L Lakkis; D Eberhart; S T Warren
Journal:  Science       Date:  1995-05-05       Impact factor: 47.728

6.  Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.

Authors:  Jennifer C Darnell; Claire E Fraser; Olga Mostovetsky; Giovanni Stefani; Thomas A Jones; Sean R Eddy; Robert B Darnell
Journal:  Genes Dev       Date:  2005-04-01       Impact factor: 11.361

7.  The fragile X mental retardation protein inhibits translation via interacting with mRNA.

Authors:  Z Li; Y Zhang; L Ku; K D Wilkinson; S T Warren; Y Feng
Journal:  Nucleic Acids Res       Date:  2001-06-01       Impact factor: 16.971

8.  A point mutation in the FMR-1 gene associated with fragile X mental retardation.

Authors:  K De Boulle; A J Verkerk; E Reyniers; L Vits; J Hendrickx; B Van Roy; F Van den Bos; E de Graaff; B A Oostra; P J Willems
Journal:  Nat Genet       Date:  1993-01       Impact factor: 38.330

9.  FMR1 protein: conserved RNP family domains and selective RNA binding.

Authors:  C T Ashley; K D Wilkinson; D Reines; S T Warren
Journal:  Science       Date:  1993-10-22       Impact factor: 47.728

10.  FXR1, an autosomal homolog of the fragile X mental retardation gene.

Authors:  M C Siomi; H Siomi; W H Sauer; S Srinivasan; R L Nussbaum; G Dreyfuss
Journal:  EMBO J       Date:  1995-06-01       Impact factor: 11.598
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  8 in total

1.  Fragile X and autism: Intertwined at the molecular level leading to targeted treatments.

Authors:  Randi Hagerman; Gry Hoem; Paul Hagerman
Journal:  Mol Autism       Date:  2010-09-21       Impact factor: 7.509

2.  Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome.

Authors:  Bing Yao; Li Lin; R Craig Street; Zachary A Zalewski; Jocelyn N Galloway; Hao Wu; David L Nelson; Peng Jin
Journal:  Hum Mol Genet       Date:  2013-10-09       Impact factor: 6.150

3.  Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles.

Authors:  Flora Tassone; Silvia De Rubeis; Chiara Carosi; Giorgio La Fata; Gisele Serpa; Christopher Raske; Rob Willemsen; Paul J Hagerman; Claudia Bagni
Journal:  Nucleic Acids Res       Date:  2011-04-07       Impact factor: 16.971

4.  Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders.

Authors:  Silvia De Rubeis; Claudia Bagni
Journal:  J Neurodev Disord       Date:  2011-08-13       Impact factor: 4.025

5.  Conformational-dependent and independent RNA binding to the fragile x mental retardation protein.

Authors:  Xin Yan; Robert B Denman
Journal:  J Nucleic Acids       Date:  2011-05-29

Review 6.  MicroRNA networks direct neuronal development and plasticity.

Authors:  N F M Olde Loohuis; A Kos; G J M Martens; H Van Bokhoven; N Nadif Kasri; A Aschrafi
Journal:  Cell Mol Life Sci       Date:  2011-08-11       Impact factor: 9.261

7.  Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome.

Authors:  Chiara Pastori; Veronica J Peschansky; Deborah Barbouth; Arpit Mehta; Jose P Silva; Claes Wahlestedt
Journal:  Hum Genet       Date:  2013-09-05       Impact factor: 4.132

8.  Normal RNAi response in human fragile x fibroblasts.

Authors:  Charlotte Madsen; Karen Grønskov; Karen Brøndum-Nielsen; Thomas G Jensen
Journal:  BMC Res Notes       Date:  2009-09-09
  8 in total

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