Literature DB >> 19631692

Reductions in paradoxical sleep time in adult rats treated neonatally with low dose domoic acid.

D A Gill1, J F Bastlund, N J Anderson, R A Tasker.   

Abstract

One hallmark of neurological dysfunction is a reduction in paradoxical sleep (PS) time. To determine if adult rats treated neonatally with low dose domoic acid have altered sleep patterns, a home cage analysis of electroencephalogram (EEG) waveforms was performed using radio telemetry. Domoate treated rats spent significantly less time in PS than controls during daytime hours even though they spent the same total amount of time sleeping, and showed no difference in stage shifts into the PS stage.

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Year:  2009        PMID: 19631692     DOI: 10.1016/j.bbr.2009.07.018

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN: 0166-4328            Impact factor:   3.332


  3 in total

1.  Progressive changes in hippocampal cytoarchitecture in a neurodevelopmental rat model of epilepsy: implications for understanding presymptomatic epileptogenesis, predictive diagnosis, and targeted treatments.

Authors:  Paul B Bernard; Leslie A Ramsay; Debra S MacDonald; R Andrew Tasker
Journal:  EPMA J       Date:  2017-08-29       Impact factor: 6.543

Review 2.  Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence.

Authors:  Rebekah Petroff; Alicia Hendrix; Sara Shum; Kimberly S Grant; Kathi A Lefebvre; Thomas M Burbacher
Journal:  Pharmacol Ther       Date:  2021-04-28       Impact factor: 12.310

3.  New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment.

Authors:  R Andrew Tasker; Amber L Adams-Marriott; Christopher A Shaw
Journal:  EPMA J       Date:  2010-06-09       Impact factor: 6.543

  3 in total

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