Literature DB >> 19631536

Synthesis and antitumor evaluation of 8-phenylaminopyrimido[4,5-c]isoquinolinequinones.

David Vásquez1, Jaime A Rodríguez, Cristina Theoduloz, Julien Verrax, Pedro Buc Calderon, Jaime A Valderrama.   

Abstract

A series of 8-phenylaminopyrimido[4,5-c]isoquinoline-7,10-quinone derivatives were prepared by regioselective amination reaction of pyrimido[4,5-c]isoquinoline-7,10-quinones with arylamines in the presence of a Lewis acid catalyst. Preliminary evaluation of the members of the series against cancer cell lines and assays of activation of their cytotoxic activity on K562 cells with ascorbic acid are reported.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19631536     DOI： 10.1016/j.bmcl.2009.07.041

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death.

Authors:  David R Vásquez; Julien Verrax; Jaime A Valderrama; Pedro Buc Calderon
Journal:  Invest New Drugs       Date:  2011-04-05       Impact factor: 3.850

2.  Access to New Cytotoxic Quinone-Amino Acid Conjugates Linked through A Vinylic Spacer from 2-Acylnaphthoquinones and Methyl 3-Aminocrotonate.

Authors:  Jaime A Valderrama; Joel Garrido; Virginia Delgado; Julio Benites; Cristina Theoduloz
Journal:  Molecules       Date:  2017-12-20       Impact factor: 4.411

3.  Synthesis and in vitro cytotoxic evaluation of aminoquinones structurally related to marine isoquinolinequinones.

Authors:  Virginia Delgado; Andrea Ibacache; Cristina Theoduloz; Jaime A Valderrama
Journal:  Molecules       Date:  2012-06-07       Impact factor: 4.411
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.