Literature DB >> 1963151

Inhibition of electrically evoked contractions of guinea-pig ileum preparations mediated by the histamine H3 receptor.

G J Menkveld1, H Timmerman.   

Abstract

We investigated the contraction responses of isolated guinea-pig ileum preparations under several conditions of electrical field stimulation. Histamine H3-agonists caused a dose-dependent inhibition of both cholinergic and nonadrenergic noncholinergic (NANC) responses (pD2 of histamine, 7.3; N alpha-methylhistamine, 8.4; (R)-alpha-methylhistamine, 8.3); H3-antagonists blocked this inhibition (pA2 of impromidine, 7.2; thioperamide, 8.5). Our results indicate that H3-receptors are present on both cholinergic and NANC nerves in the myenteric plexus and that the preparation can be used as a rapid and simple test system for histamine H3-receptors.

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Year:  1990        PMID： 1963151     DOI： 10.1016/0014-2999(90)90458-i

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

Review 1.  An update on histamine H3 receptors and gastrointestinal functions.

Authors:  G Bertaccini; G Coruzzi
Journal:  Dig Dis Sci       Date:  1995-09       Impact factor: 3.199

2.  Pharmacological profile of new thioperamide derivatives at histamine peripheral H1-, H2-, H3-receptors in guinea-pig.

Authors:  E Barocelli; V Ballabeni; A Caretta; F Bordi; C Silva; G Morini; M Impicciatore
Journal:  Agents Actions       Date:  1993-03

3.  Histamine selectively enhances human immunoglobulin E (IgE) and IgG4 production induced by anti-CD58 monoclonal antibody.

Authors:  H Kimata; M Fujimoto; C Ishioka; A Yoshida
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307

4.  Characterization of histamine-H3 receptors controlling non-adrenergic non-cholinergic contractions of the guinea-pig isolated ileum.

Authors:  S J Taylor; G J Kilpatrick
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

5.  Inhibition of sympathetic hypertensive responses in the guinea-pig by prejunctional histamine H3-receptors.

Authors:  J A Hey; M del Prado; R W Egan; W Kreutner; R W Chapman
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

6.  Activation of histamine H3 receptors produces presynaptic inhibition of neurally evoked cat nictitating membrane responses in vivo.

Authors:  M C Koss; J A Hey
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-08       Impact factor: 3.000

7.  H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.

Authors:  A Bado; L Moizo; J P Laigneau; J Delwaide; M J Lewin
Journal:  Yale J Biol Med       Date:  1994 May-Aug
  7 in total

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