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Literature DB >> 1963103

The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats.

Abstract

Peripheral-type benzodiazepine (BZD) receptors were studied in cultured astrocytes derived from genetically epilepsy-prone and control rats. Scatchard analysis of the binding of [3H]Ro 5-4864 to astrocyte homogenates from epilepsy-prone rats showed 38% fewer BZD receptors (Bmax) as compared to controls. No significant change in affinity (Kd) was observed. These findings suggest that the astrocyte peripheral-type BZD receptor may be involved in some forms of epilepsy.

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Year: 1990 PMID： 1963103 DOI： 10.1016/0006-8993(90)90793-b

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

19 in total

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2. Effects of ammonia on L-glutamate uptake in cultured astrocytes.

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Authors: Arumugam R Jayakumar; Xiao Y Tong; Kevin M Curtis; Roberto Ruiz-Cordero; Nagarajarao Shamaladevi; Missa Abuzamel; Joshua Johnstone; Gabriel Gaidosh; Kakulavarapu V Rama Rao; Michael D Norenberg
Journal: J Neurochem Date: 2014-08-01 Impact factor: 5.372

4. Sulfonylurea receptor 1 contributes to the astrocyte swelling and brain edema in acute liver failure.

Authors: A R Jayakumar; V Valdes; X Y Tong; N Shamaladevi; W Gonzalez; M D Norenberg
Journal: Transl Stroke Res Date: 2014-01-18 Impact factor: 6.829

5. Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy.

Authors: A R Jayakumar; X Y Tong; J Ospel; M D Norenberg
Journal: Neuroscience Date: 2012-05-17 Impact factor: 3.590

The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats.

1. Brain aquaporin-4 in experimental acute liver failure.

2. Effects of ammonia on L-glutamate uptake in cultured astrocytes.

3. Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies.

4. Sulfonylurea receptor 1 contributes to the astrocyte swelling and brain edema in acute liver failure.

5. Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy.

6. The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.

7. NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture.

8. Microglia contribute to ammonia-induced astrocyte swelling in culture.

9. Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes.

10. Calcium in the mechanism of ammonia-induced astrocyte swelling.