| Literature DB >> 19631029 |
Narges Rashidi1, Gregor B Adams.
Abstract
Adult hematopoietic stem cells (HSCs) reside in the bone marrow in stable microenvironments known as the stem cell niche. One key component of the stem cell niche is cells of the osteoblastic lineage. Factors that are known to affect osteoblast activity, such as parathyroid hormone (PTH), have also been shown to affect the HSCs. Treatment of mice with PTH has led to beneficial effects on the HSC pool, which have led to clinical trials of PTH treatment to enhance HSC-based therapies.Entities:
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Year: 2009 PMID: 19631029 DOI: 10.1007/s11914-009-0010-7
Source DB: PubMed Journal: Curr Osteoporos Rep ISSN: 1544-1873 Impact factor: 5.096