PURPOSE: To determine if differences exist between control and diabetic rats in functional magnetic resonance imaging (fMRI) activity of the spinal cord and if fMRI can provide a means of early detection of diabetic neuropathy. MATERIALS AND METHODS: fMRI of the spinal cord, using noxious electrical stimulation (15 V ( approximately 8 mA), 0.3 msec, 3 Hz) of the hind paw, was performed in groups of control and streptozotocin (STZ)-induced type 1 diabetic rats. RESULTS: Diabetic rats were lighter, hyperglycemic, and had lower blood pH than controls. fMRI activity at the lumbar enlargement of the spinal cord was identified in the dorsal horn ipsilateral to stimulus of all animals. Signal intensity changes across the lumbar spinal cord during periods of activity were not significantly different between control and diabetic rats, with a trend toward greater signal changes in controls. When specific regions of the spinal cord were analyzed, control rats exhibited significantly increased blood-oxygen level-dependent (BOLD) fMRI activity in both ipsilateral and contralateral dorsal horn compared to diabetic rats. CONCLUSION: The results of this study are consistent with reports that primary afferent input to the spinal cord is diminished by diabetes, and suggest that BOLD fMRI may be useful in early detection of diabetic neuropathy. (c) 2009 Wiley-Liss, Inc.
PURPOSE: To determine if differences exist between control and diabeticrats in functional magnetic resonance imaging (fMRI) activity of the spinal cord and if fMRI can provide a means of early detection of diabetic neuropathy. MATERIALS AND METHODS: fMRI of the spinal cord, using noxious electrical stimulation (15 V ( approximately 8 mA), 0.3 msec, 3 Hz) of the hind paw, was performed in groups of control and streptozotocin (STZ)-induced type 1 diabeticrats. RESULTS:Diabeticrats were lighter, hyperglycemic, and had lower blood pH than controls. fMRI activity at the lumbar enlargement of the spinal cord was identified in the dorsal horn ipsilateral to stimulus of all animals. Signal intensity changes across the lumbar spinal cord during periods of activity were not significantly different between control and diabeticrats, with a trend toward greater signal changes in controls. When specific regions of the spinal cord were analyzed, control rats exhibited significantly increased blood-oxygen level-dependent (BOLD) fMRI activity in both ipsilateral and contralateral dorsal horn compared to diabeticrats. CONCLUSION: The results of this study are consistent with reports that primary afferent input to the spinal cord is diminished by diabetes, and suggest that BOLD fMRI may be useful in early detection of diabetic neuropathy. (c) 2009 Wiley-Liss, Inc.
Authors: Jane Lawrence; Patrick W Stroman; Saro Bascaramurty; Larry M Jordan; Krisztina L Malisza Journal: Neuroimage Date: 2004-08 Impact factor: 6.556
Authors: Krisztina L Malisza; Patrick W Stroman; Allan Turner; Lori Gregorash; Tadeusz Foniok; Anthony Wright Journal: J Magn Reson Imaging Date: 2003-08 Impact factor: 4.813
Authors: Tung-Lin Wu; Feng Wang; Arabinda Mishra; George H Wilson; Nellie Byun; Li Min Chen; John C Gore Journal: Magn Reson Med Date: 2017-09-14 Impact factor: 4.668