| Literature DB >> 19629467 |
Xiaohua Yan1, Liyun Xu, Jianni Qi, Xiaohong Liang, Chunhong Ma, Chun Guo, Lining Zhang, Wensheng Sun, Jiyun Zhang, Xiaoyi Wei, Lifen Gao.
Abstract
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily, and has been identified as a novel mediator of fatty liver disease (FLD). The aim of our study was to further investigate the relationship between TRAIL and FLD. We found that soluble TRAIL (sTRAIL) concentrations in non-alcoholic FLD (NAFLD) patients were significantly higher than those of controls, and that sTRAIL levels positively correlated with triglyceride concentrations in NAFLD patients. Our results also indicated that the AA/TT genotypes of TRAIL at 1525/1595 engendered a lower risk of FLD attack and a less severe form of steatosis for NAFLD patients in Chinese population. This study provides a means to test for susceptibility to FLD and may assist in the diagnosis of FLD. In addition, we found that 1525G/A and 1595C/T sites were in complete linkage disequilibrium in Chinese population. This might indicate a haplotype with high genetic frequency of TRAIL.Entities:
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Year: 2009 PMID： 19629467 DOI： 10.1007/s00251-009-0389-4
Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846